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Key Documents

SAB4500758

Sigma-Aldrich

Anti-PIP5K antibody produced in rabbit

affinity isolated antibody

Sinónimos:

1- phosphatidylinositol-4-phosphate 5-kinase, FYV1, FYVE finger-containing phosphoinositide kinase, KIAA0981, PIKfyve

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 237 kDa

species reactivity

mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

Q9Y2I7

UniProt accession no.

Q9Y2I7

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PIKFYVE(200576)

General description

PIKFYVE belongs to an evolutionarily ancient gene family of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2)enzymes. PIKFYVE gene is located on human chromosome 2q34. Anti-PIP5K antibody detects endogenous levels of total PIP5K protein.

Immunogen

The antiserum was produced against synthesized peptide derived from human PIP5K.

Immunogen Range: 71-120

Biochem/physiol Actions

Phosphatidylinositol 4-phosphate 5-kinase (PIP5K)/Phosphoinositide kinase, FYVE-type zinc finger containing (PIKFYVE) protein plays a key role in phosphoinositide 5-kinase and protein kinase activity. It is essential for post-Golgi vesicle processing. Mutation in the PIKFYVE gene is associated with fleck corneal dystrophy (FCD).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Alicia Cabezas et al.
Gene, 371(1), 34-41 (2006-02-02)
Yeast Fab1 is a phosphatidylinositol 3-phosphate 5-kinase involved in endocytic membrane traffic and vacuole homeostasis. Here we have cloned and sequenced the cDNA for the human homologue of Fab1, PIKfyve. The cDNA has an open reading frame of 6294 bp
Jessica A Gee et al.
Molecular vision, 21, 1093-1100 (2015-09-24)
To report the identification of a novel frameshift mutation and copy number variation (CNV) in PIKFYVE in two probands with fleck corneal dystrophy (FCD). Slit-lamp examination was performed to identify characteristic features of FCD. After genomic DNA was collected, PCR
Andreas Kotoulas et al.
Molecular vision, 17, 2776-2781 (2011-11-09)
To report the findings of the clinical and molecular evaluation in a Greek family with fleck corneal dystrophy (CFD). A 58-year-old woman was seen on routine ophthalmic examination and diagnosed as having CFD. All available family members were examined to

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