S0802
Stearoyl coenzyme A lithium salt
≥90%
Sinónimos:
n-Octadecanoyl Coenzyme A
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About This Item
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Application
Coenzyme A functions as an acyl group carrier, acetyl-CoA. Stearoyl CoA is a saturated fatty acid metabolite involved in polyunsaturated fatty acid synthesis and the PPAR signaling pathway. Stearoyl CoA is used to study the specificity and kinetics of stearoyl-CoA desaturase(s) which lead to the formation of monounsaturated fatty acids.
Stearoyl coenzyme A lithium salt may be used as a substrate in the stearoyl-CoA desaturase assay in microsomes.
Biochem/physiol Actions
Stearoyl CoA is a saturated fatty acid metabolite involved in polyunsaturated fatty acid synthesis and the PPAR signaling pathway. Stearoyl CoA is a substrate for the enzyme stearoyl-CoA desaturase. Stearoyl CoA desaturation is the crucial step in unsaturated fatty acid biosynthesis. Stearoyl CoA is converted to oleoyl-CoA by stearoyl-CoA desaturase.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy
Molecular Cancer Research, 9(11), 1551-1561 (2011)
Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
Proceedings of the National Academy of Sciences of the USA, 99(17), 11482-11486 (2002)
European journal of pharmacology, 672(1-3), 38-44 (2011-10-06)
Stearoyl-CoA desaturase1 (SCD1) whole body deficiency protects mice from diet-induced obesity. However the specific mechanism of how SCD1 deficiency protects mice from obesity is not clear yet. To understand the tissue-specific role of SCD1 in energy homeostasis, we investigated the
Genes & nutrition, 7(2), 209-216 (2011-11-08)
Consumption of trans fatty acids is positively correlated with cardiovascular diseases and with atherogenic risk factors. Trans fatty acids might play their atherogenic effects through lipid metabolism alteration of vascular cells. Accumulation of lipids in vascular smooth muscle cells is
The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1
The Journal of Biological Chemistry, 275(39), 30132-30138 (2000)
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