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P7903

Sigma-Aldrich

Pipemidic acid

Sinónimos:

8-Ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylic acid

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About This Item

Fórmula empírica (notación de Hill):
C14H17N5O3
Número de CAS:
51940-44-4
Peso molecular:
303.32
Número CE:
257-530-2
Número MDL:
MFCD00057291
Código UNSPSC:
51282938
ID de la sustancia en PubChem:
24898889
NACRES:
NA.85

Formulario

powder

espectro de actividad antibiótica

Gram-negative bacteria
Gram-positive bacteria

Modo de acción

DNA synthesis | interferes
cell wall synthesis | interferes
enzyme | inhibits

cadena SMILES

CCN1C=C(C(O)=O)C(=O)c2cnc(nc12)N3CCNCC3

InChI

1S/C14H17N5O3/c1-2-18-8-10(13(21)22)11(20)9-7-16-14(17-12(9)18)19-5-3-15-4-6-19/h7-8,15H,2-6H2,1H3,(H,21,22)

Clave InChI

JOHZPMXAZQZXHR-UHFFFAOYSA-N

Información sobre el gen

human ... CYP1A2(1544)

Descripción general

Chemical structure: quinolone

Aplicación

Pipemidic acid is used to study DNA damage and mutagenic activity[1]. It has been used to induce articular lesions in the neonatal mouse[2] and is used to study human lymphocyte blastogenesis and γ-interferon production [3].

Acciones bioquímicas o fisiológicas

Pipemidic acid modulates (inhibits) bacterial DNA gyrase-dependent processes such as DNA polymerization, (ATP-dependent) DNA supercoiling, and chromosome fragmentation. Pipemidic acid has been shown to induce inhibition of lymphocyte DNA synthesis[3].

Nota de análisis

Very slightly soluble in water. It dissolves in diluted solutions of acids and of alkali hydroxides.

Otras notas

10g,100g
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

Pictogramas

Health hazard
GHS08

Palabra de señalización

Danger

Frases de peligro

H317,H334

Clasificaciones de peligro

Resp. Sens. 1 - Skin Sens. 1

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000203132
0000203132
0000135966
0000085644
089M4806V

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Jin Sun et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 64(2), 238-245 (2006-08-01)
This study described distribution characteristics of olamufloxacin (HSR-903) in lung epithelial lining fluid (ELF) and alveolar macrophage (AM) in rats, two important representative infectious sites in lower respiratory tract infections. The rats were orally administered at a dose of 10mg/kg.
A Maura et al.
Mutagenesis, 3(5), 397-401 (1988-09-01)
The mutagenic and DNA-damaging activities of oxolinic acid and pipemidic acid were evaluated in the rat granuloma pouch assay. After oral administration at high doses both the chemicals produce DNA alkali-labile sites in granuloma tissue cells, and with oxolinic acid
Adrienne B Hoeglund et al.
Journal of medicinal chemistry, 53(3), 1056-1066 (2010-01-01)
Autotaxin (ATX, NPP2) has recently been shown to be the lysophospholipase D responsible for synthesis of the bioactive lipid lysophosphatidic acid (LPA). LPA has a well-established role in cancer, and the production of LPA is consistent with the cancer-promoting actions
Margherita Lavorgna et al.
International journal of molecular sciences, 20(2) (2019-01-24)
Pipemidic acid (HPPA) is a quinolone antibacterial agent used mostly to treat gram-negative infections of the urinary tract, but its therapeutic use is limited because of its low solubility. Thus, to improve drug solubility, natural cyclodextrins (CDs) are used for
Juan Li et al.
Environmental health perspectives, 120(8), 1144-1149 (2012-05-10)
Inappropriate use of antibiotics in swine feed could cause accelerated emergence of antibiotic resistance genes, and agricultural application of swine waste could spread antibiotic resistance genes to the surrounding environment. We investigated the distribution of plasmid-mediated quinolone resistance (PMQR) genes
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