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Merck

N4788

Sigma-Aldrich

Anti-NOTCH1 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-Notch homolog 1 (Drosophila), Anti-TAN1

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

reactividad de especies

mouse, human, rat

concentración

~1 mg/mL

técnicas

immunohistochemistry: 1:100-1:200
western blot: 1:500-1:1,000

Nº de acceso UniProt

aplicaciones

research pathology

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... NOTCH1(4851)
mouse ... Notch1(18128)
rat ... Notch1(25496)

Descripción general

NOTCH homolog-1 (NOTCH-1) is a transmembrane receptor.

Inmunógeno

synthetic peptide corresponding to residues 2170-2187 of human NOTCH1.

Acciones bioquímicas o fisiológicas

NOTCH homolog-1 (NOTCH-1) is an integral part of the NOTCH signaling pathway, which regulates various cellular functions. NOTCH-1 enhances the invasion of cancer cells and mutations in the gene encoding it have been associated with chronic lymphocytic leukemia (CLL).

Forma física

solution in phosphate buffered saline, containing 0.02% sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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John J Arcaroli et al.
International journal of cancer, 138(1), 195-205 (2015-07-15)
Dysregulation of the Notch1 receptor has been shown to facilitate the development and progression of colorectal cancer (CRC) and has been identified as an independent predictor of disease progression and worse survival. Although mutations in the NOTCH1 receptor have not
Zhiming Zhuang et al.
Oncology letters, 14(3), 3437-3444 (2017-09-21)
Notch 1 is a key component of the Notch pathway, which performs a crucial role in clear cell renal cell carcinoma (CCRCC) development. The present study aimed to investigate whether Notch 1 could serve as a potential target for CCRCC
Wei Xu et al.
International journal of clinical and experimental pathology, 8(3), 2737-2745 (2015-06-06)
We aimed to investigate the role of Notch1/Hes signaling pathway in the pathogenesis of abnormal ossification of hip ligament in patients with ankylosing spondylitis (AS). 22 AS patients scheduled for artificial hip arthroplasty were randomly chosen as AS group. As
Zhen-Shu Xu et al.
Oncology reports, 33(4), 1609-1614 (2015-01-31)
NOTCH1 mutations occur in approximately 10% of patients with chronic lymphocytic leukemia (CLL). However, the relationship between the genetic aberrations and tumor cell drug resistance or disease progression remains unclear. Frameshift deletions were detected by gene sequencing in the NOTCH1
Huiqiu Cao et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 120(6), 441-450 (2012-05-16)
Notch receptor signaling pathway (NRSP) is increasingly linked to carcinogenesis. Non-small cell lung cancer (NSCLC) appears to actively utilize this conserved developmental pathway. The aims of this study are to determine whether or not Notch 1-4 are overexpressed in NSCLC

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