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Merck

N4505

Sigma-Aldrich

β-Nicotinamide adenine dinucleotide, reduced dipotassium salt

Sinónimos:

β-DPNH, β-NADH, DPNH, Diphosphopyridine nucleotide, reduced form, NADH

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100 MG
US$ 272,00
500 MG
US$ 458,00
1 G
US$ 848,00

US$ 272,00

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Disponible para envío el11 de abril de 2025Detalles


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100 MG
US$ 272,00
500 MG
US$ 458,00
1 G
US$ 848,00

About This Item

Fórmula lineal:
C21H27N7O14P2K2
Número de CAS:
Peso molecular:
741.62
Número MDL:
Código UNSPSC:
41106305
ID de la sustancia en PubChem:
NACRES:
NA.51

US$ 272,00

PRECIOS SIN IMPUESTOS NACIONALES

Disponible para envío el11 de abril de 2025Detalles


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origen biológico

synthetic

Ensayo

≥95%

Formulario

powder

solubilidad

10 mM NaOH: soluble-100 mg/mL, clear to hazy, faintly yellow to yellow

temp. de almacenamiento

−20°C

cadena SMILES

[K].NC(=O)C1=CN(C=CC1)C2OC(COP(O)(=O)OP(O)(=O)OCC3OC(C(O)C3O)n4cnc5c(N)ncnc45)C(O)C2O

InChI

1S/C21H29N7O14P2.K.H/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33;;/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25);;

Clave InChI

KMRPNNQOKAHXEZ-UHFFFAOYSA-N

Información sobre el gen

human ... IMPDH2(3615)

Aplicación

β-Nicotinamide adenine dinucleotide (NAD+) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases).

Acciones bioquímicas o fisiológicas

Electron donor

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Luisa Schwarzmann et al.
Bioscience reports, 41(1) (2021-01-05)
Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic reactions and cosubstrate in signaling pathways of cells. While the intracellular function of NAD is well described, much less is known about its importance as an extracellular molecule. Moreover, there is
Cornelia Wetzker et al.
Scientific reports, 9(1), 19534-19534 (2019-12-22)
Metabolic profiles vary across all levels of biological diversity, from cells to taxa. Two-photon fluorescence lifetime imaging microscopy (FLIM) facilitates metabolic characterisation of biological specimens by assaying the intrinsic autofluorescence of the ubiquitous coenzymes NAD(P)H and FAD. The potential of
Sritama De Sarkar et al.
Parasitology research, 118(1), 335-345 (2018-11-25)
Berberine chloride, a plant-derived isoquinoline alkaloid, has been demonstrated to have leishmanicidal activity, which is mediated by generation of a redox imbalance and depolarization of the mitochondrial membrane, resulting in a caspase-independent apoptotic-like cell death. However, its impact on mitochondrial
Erika Chacin et al.
Nature communications, 12(1), 5224-5224 (2021-09-03)
The replication of chromosomes during S phase is critical for cellular and organismal function. Replicative stress can result in genome instability, which is a major driver of cancer. Yet how chromatin is made accessible during eukaryotic DNA synthesis is poorly
Peter M Fernandes et al.
The FEBS journal, 287(13), 2847-2861 (2019-12-16)
Trypanosomatids possess glycosome organelles that contain much of the glycolytic machinery, including phosphofructokinase (PFK). We present kinetic and structural data for PFK from three human pathogenic trypanosomatids, illustrating intriguing differences that may reflect evolutionary adaptations to differing ecological niches. The

Questions

1–4 of 4 Questions  
  1. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  2. What is the extinction coefficient for Product N4505, β-Nicotinamide adenine dinucleotide, reduced dipotassium salt?

    1 answer
    1. EmM = 6.22 (340 nm) and 14.4 (259 nm, pH 9.5)

      Helpful?

  3. What information do you have on the solubility and solution stability of Product N4505, β-Nicotinamide adenine dinucleotide, reduced dipotassium salt?

    1 answer
    1. Solubility and solution stability information can be found on the product information sheet (under Documents, above).

      Helpful?

  4. What is the absorption maximum and the fluorescence emission maximum wavelengths for Product N4505, β-Nicotinamide adenine dinucleotide, reduced dipotassium salt?

    1 answer
    1. The absorption maximum for NADH is at 340 nm and the fluorescence emission maximum is at 460 nm.

      Helpful?

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