N7004

βDinucleótido de β-nicotinamida y adenina hydrate

≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast

• Sinónimos: β-DPN, β-NAD, -NAD, Coenzima 1, Cozimasa, DPN, Nadide, Nucleótido de difosfopiridina
• Fórmula empírica (notación de Hill): C₂₁H₂₇N₇O₁₄P₂ · xH₂O
• Número de CAS: 53-84-9
• Peso molecular: 663.43 (anhydrous basis)
• Número MDL: MFCD00036253
• Código UNSPSC: 41106305
• eCl@ss: 39200202
• ID de la sustancia en PubChem: 24897803
• NACRES: NA.55

Propiedades

• origen biológico: yeast
• Nivel de calidad: 300
• Ensayo: ≥96.5% (HPLC); ≥96.5% (spectrophotometric assay)
• Formulario: powder
• puntuación de productos alternativos más sostenibles: old score: 56; new score: 20; Find out more about DOZN™ Scoring
• características de los productos alternativos más sostenibles: Waste Prevention; Less Hazardous Chemical Syntheses; Safer Solvents and Auxiliaries; Design for Energy Efficiency; Use of Renewable Feedstocks; Inherently Safer Chemistry for Accident Prevention; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• color: white to off-white
• aplicaciones: metabolomics
• categoría alternativa más sostenible: Re-engineered,
• temp. de almacenamiento: −20°C
• cadena SMILES: NC1=NC=NC2=C1N=CN2.O[C@@H]3[C@@H](COP(O)(OP(OC[C@@H](O4)[C@@H](O)[C@@H](O)[C@H]4[N+]5=CC=CC(C(N)=O)=C5)([O-])=O)=O)OC[C@@H]3O
• InChI: 1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1
• Clave InChI: BAWFJGJZGIEFAR-NNYOXOHSSA-N
• Información sobre el gen: human ... ESR1(2099) , ESR2(2100)

Descripción

Descripción general

Nicotinamide adenine dinucleotide (NAD) is a vital coenzyme that transcends its traditional role as an "electron carrier," influencing diverse cellular processes. In cell biology, NAD operates as a crucial electron acceptor in the electron transport chain, driving the production of ATP, the cell′s primary energy source. This electron flow sustains basic cellular maintenance and complex signaling pathways. Beyond its energetic role, NAD serves as a dynamic signaling molecule, dictating cellular responses to various stimuli. Fluctuations in NAD concentration trigger events in DNA repair, gene expression, and cell death, allowing cells to adapt to stress and maintain homeostasis.

In biochemical research, NAD emerges as a vital cofactor for enzymes like sirtuins, poly(ADP-ribose) polymerases, and cADP-ribose synthases. These enzymes rely on NAD+ for catalytic activity, influencing processes such as protein deacetylation, DNA repair, and cellular signaling. In metabolomics, NAD plays a key role in metabolic pathways, making it a significant focus for understanding cellular metabolism comprehensively. NAD participates in additional intricate cellular processes, serving as a substrate for ADP-ribosylation—a post-translational modification affecting protein function. It also acts as a precursor for cyclic ADP-ribose, a second messenger molecule involved in calcium mobilization and cell communication. Research on NAD holds promise across various areas, including aging, where its role is actively investigated. Studies also explore its implications in neurodegenerative disorders and metabolic imbalances.

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Less Hazardous Chemical Syntheses”, “Safer Solvents and Auxiliaries”, “Enhanced Energy Efficiency”, “Use of Renewable Feedstocks” and “Inherently Safer Chemistry for Accident Prevention”. Click here to view its DOZN scorecard.

Aplicación

β-Nicotinamide adenine dinucleotide hydrate has been used:

• to prepare NAD+ standard solution for a study on NAD+ metabolomics[1]
• as a component of MurI assay reaction partial mixture for glutamate racemase reaction[2]
• as a component of a chromogenic staining solution to stain zebrafish embryos[3]

Acciones bioquímicas o fisiológicas

Aceptor de electrones

Características y beneficios

Versatile and adaptable for a wide variety of laboratory and research applications.

Envase

Envasado por peso sólido.

Nota de preparación

To prepare a solution gentle heating and sonication may be necessary.

Otras notas

Esta es la forma común del NAD.

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Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable