This product can be solubilized at 50 mg/ml of 1M ammonium hydroxide. This product can also be
solubilized in water at 2mg/ml forming a clear to slightly hazy colorless solution. Solubility may be increased to at least 10mg/ml by solubilizing in either dilute acid or base. It is probably preferable to prepare a slightly acidic solution since this would maintain the amine group as a quaternary amine, which is less prone to oxidation. These solutions may be stored short term in the refrigerator or long term as frozen aliquots. Specifics around in vivo and/or in vitro applications have not been determined for this product. Consult the scientific literature for further information around the use of this product in these applications. You can find "Peer Reviewed Papers" near the bottom of this product's webpage for help in your search for more information.
M0253
L-Mimosine from Koa hoale seeds
≥98%
Sinónimos:
(S)-α-Amino-β-[1-(3-hydroxy-4-oxopyridine)]propionic acid, Leucenol
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25 MG
US$ 44,80
100 MG
US$ 114,00
500 MG
US$ 287,00
1 G
US$ 571,00
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25 MG
US$ 44,80
100 MG
US$ 114,00
500 MG
US$ 287,00
1 G
US$ 571,00
About This Item
Fórmula empírica (notación de Hill):
C8H10N2O4
Número de CAS:
Peso molecular:
198.18
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.77
Productos recomendados
Quality Level
assay
≥98%
SMILES string
N[C@@H](CN1C=CC(=O)C(O)=C1)C(O)=O
InChI
1S/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)/t5-/m0/s1
InChI key
WZNJWVWKTVETCG-YFKPBYRVSA-N
General description
L-mimosine [β-N (3-hydroxy-4-pyridone)-α-amino propionic acid] is a non-protein amino acid and is a vital component of tropical legumes, such as Leucaena glauca and other legumes belonging to Mimosa spp. Structurally L-mimosine resembles dihydroxyphenylalanine except 3,4-dihydroxy-phenyl ring replaced by 3-hydroxy-4-pyridone ring.[1]
application
L-Mimosine from Koa hoale seeds has been used to study its anti-inflammatory effect in chronic inflammatory response (potassium permanganate - induced chronic granuloma).[2]
Biochem/physiol Actions
L-Mimosine is a plant amino acid and potential inhibitor of the cell cycle giving rise to growth arrest in G1-phase.[3] It is an iron chelator that inhibits DNA replication in mammalian cells.[4] L-Mimosine has been shown to promote apoptosis in xenotransplanted human pancreatic cancer.[5] L-Mimosine stabilizes hypoxia inducible factor 1 (HIF-1) and stimulates the expression of B-cell translocation gene 2 (Btg2) and N-myc downstream regulated gene 1 (Ndrg1) at the transcriptional level, which reduce cell proliferation of prostate carcinoma cells in vitro. L-Mimosine stabilizes HIF-1 through the inhibition of prolyl hydroxylases (PHDs) which target HIF-1 through degradation.[3] The mechanism of inhibition is likely through the chelation of Fe2+ bound to the active site of PHD which is required for enzymatic activity. Mimosine inhibits cell cycle progression via iron chelation in MDA-MB-453 human breast cancer cells.[6] Mimosine, hinder folate metabolism in cell-specific manner.[4]
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Los clientes también vieron
Li-Chuan Chung et al.
American journal of physiology. Cell physiology, 302(4), C676-C685 (2011-11-26)
L-Mimosine, an iron chelator and a prolyl 4-hydroxylase inhibitor, blocks many cancer cells at the late G1 phase. B-cell translocation gene 2 (Btg2) regulates the G1/S transition phases of the cell cycle. N-myc downstream regulated gene 1 (Ndrg1) is a
Tian-Xia Jiang et al.
Theranostics, 11(3), 1458-1472 (2021-01-05)
The epigenetic inheritance relies on stability of histone marks, but various diseases, including aging-related disorders, are usually associated with alterations of histone marks. Whether and how the proteasome is responsible for maintaining the histone marks during transcription and aging remain
Mimosine, a plant-derived amino acid induces apoptosis in human pancreatic cancer xenografts.
Zalatnai A and Bocsi J.
Anticancer Research, 23(5A), 4007-4009 (2003)
H Agis et al.
Journal of periodontal research, 47(2), 165-173 (2011-10-01)
Pharmacological inhibitors of prolyl hydroxylases (PHDs) can induce a proangiogenic response that favors wound healing and bone regeneration. However, the response of periodontal cells to PHD inhibitors is unknown. To determine the effects of PHD inhibitors on periodontal cells, we
Li-Chuan Chung et al.
Molecular nutrition & food research, 55(11), 1666-1676 (2011-09-22)
Prostate-specific antigen (PSA) is a well-known marker for diagnosing and monitoring prostate cancer. Curcumin, a yellow curry pigment, has been reported to enhance androgen receptor (AR) degradation. We examined the effects of curcumin on increasing PSA expression by hypoxia and
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Dear Sigma, We would like to know what solvent can be used to dissolve M0253 L-Mimosine into solution? What working concentrations are recommended to use in vivo and in cells respectively? What maximal concentrations have been used without toxicity ?
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