I9032
Interferon β from mouse
≥95%, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture
Sinónimos:
IFN β
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origen biológico
mouse
Nivel de calidad
recombinante
expressed in E. coli
Ensayo
≥95%
Formulario
buffered aqueous solution
mol peso
~20 kDa
envase
pkg of 1 vial
concentración
2560000 units/mL
técnicas
cell culture | mammalian: suitable
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
Información sobre el gen
mouse ... Ifnb1(15977)
Descripción general
IFN β (interferon β) is from the type 1 interferon family of cytokines.[1]
Interferon β (IFN-β) possesses a signal peptide region. It has comparatively more hydrophobic residues and displays 30% homology with IFN-α.[2]
The gene encoding interferon β (Infb1) is localized on mouse chromosome 4.[3]
Aplicación
Interferon β from mouse has been used:
- in the stimulation of bone marrow-derived dendritic cells (BMDCs)[4]
- as a cytokine to stimulate differentiation of podocytes[5]
- to stimulate splenocytes[6]
Interferon ß from mouse has been used:
- to induce the activation of cholesterol 25-hydroxylase, by in vitro stimulation of bone marrow-derived macrophages, dendritic cells and CD11c+ lung macrophages[4]
- to stimulate splenocytes, in order to study the secretion and regulation of IFN-γ [7]
- to intranasally pre-treat neonatal mice, to study its effects on the protective actions of Lactobacillus rhamnosus GG (LGG)[8]
- as a standard to treat MEF-Mx2-luc-BKO reporter cell line for IFN-β measurement, in response to human adenovirus-5 (HAdV-C5)[9]
Acciones bioquímicas o fisiológicas
Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.
In presence of virus infection, IFN β (interferon β) is upregulated and plays a crucial role in innate antiviral response.[10] It is also important for anti-inflammatory effects.[1]
Interferon β (IFN-β) suppresses a variety of proinflammatory cytokines in lymphocytes including the interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α).[11] It also favors the synthesis of antagonists associated with interleukin IL-10 and IL-1 receptor.[11] IFN-β downregulates interferon γ production but enhances transforming growth factor β1 expression.[11] It has therapeutic potential in treating rheumatoid arthritis[11] and relapsing-remitting multiple sclerosis (MS).[12]
Forma física
Solution in 20 mM HEPES, pH 6.0, 0.5 M NaCl, 6% glycerol, and 0.1% bovine serum albumin.
Nota de análisis
The biological activity is determined in the cytopathic effect inhibition assay using mouse L929 cells with encephalomyocarditis virus. The cytopathic effect of 50% is produced with approximately 1 unit/ml interferon. The units are determined with respect to NIH international standard reference for mouse interferon β.
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Nanthapon Ruangkiattikul et al.
Virulence, 8(7), 1303-1315 (2017-04-20)
Type I interferons (IFN-I), such as IFN-α and IFN-β are important messengers in the host response against bacterial infections. Knowledge about the role of IFN-I in infections by nontuberculous mycobacteria (NTM) is limited. Here we show that macrophages infected with
Manuel Hagen et al.
Cell cycle (Georgetown, Tex.), 15(14), 1929-1937 (2016-05-28)
Podocytes are terminally differentiated renal cells, lacking the ability to regenerate by proliferation. However, during renal injury, podocytes re-enter into the cell cycle but fail to divide. Earlier studies suggested that re-entry into cell cycle results in loss of podocytes
P Keskinen et al.
Immunology, 91(3), 421-429 (1997-07-01)
HLA class I and II molecules play a central role in regulating host immune responses against microbial infections because they present foreign antigens to CD8+ and CD4+ T lymphocytes, respectively. Many cytokines, especially interferons (IFN), are known to upregulate human
ENU-induced mutation in USP18 causes hyperactivation of IFN-alphabeta signalling and suppresses STAT4-induced IFN-gamma production resulting in increased susceptibility to Salmonella Typhimurium
Richer E, et al.
Journal of immunology (Baltimore, Md. : 1950), 185(6), 3593-3593 (2010)
Vasco Marcato et al.
Molecular and cellular biology, 36(1), 13-29 (2015-10-16)
Rapid upregulation of interferon beta (IFN-β) expression following virus infection is essential to set up an efficient innate antiviral response. Biological roles related to the antiviral and immune response have also been associated with the constitutive production of IFN-β in
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