I1636
Anti-Human IgM (μ-chain specific) antibody produced in goat
whole antiserum
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About This Item
Productos recomendados
biological source
goat
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
secondary antibodies
clone
polyclonal
contains
15 mM sodium azide
technique(s)
indirect ELISA: 1:100,000
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
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General description
Immunoglobulin M (IgM) is the major component of antibodies. It is the first antibody to be secreted during a primary antibody response, which is expressed in the human fetus. IgM is produced by B1 cells, which is found in blood.
Specificity
The antibody preparation is specific for human IgM when tested against purified human IgA, IgG, Bence Jones Kappa and Bence Jones Lambda light chains
Biochem/physiol Actions
IgM antibodies are present as pentamers in the serum and are produced in response to antigens.
Immunoglobulin M (IgM) pentamer activates the classical pathway of complement activation and lysis of red blood cells. Monoclonal IgM antibodies provides protection against systemic infection and autoimmune diseases. It does not cross human placenta. IgM regulates B cell development.
Physical form
Supplied as a liquid containing 15 mM sodium azide as a preservative.
Storage and Stability
For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Role of natural and immune IgM antibodies in immune responses
Boes M, et al.
Molecular Immunology, 37(18), 1141-1149 (2000)
The immunological development of the human fetus
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