H6036

1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole

powder, ≥98% (HPLC)

• Sinónimos: PPT
• Fórmula empírica (notación de Hill): C₂₄H₂₂N₂O₃
• Número de CAS: 263717-53-9
• Peso molecular: 386.44
• Número MDL: MFCD03453628
• Código UNSPSC: 51111800
• ID de la sustancia en PubChem: 24278470
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to tan
• solubilidad: DMSO: soluble 20 mg/mL; H₂O: insoluble
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CCCc1c(nn(-c2ccc(O)cc2)c1-c3ccc(O)cc3)-c4ccc(O)cc4
• InChI: 1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,27-29H,2-3H2,1H3
• Clave InChI: IOTXSIGGFRQYKW-UHFFFAOYSA-N
• Información sobre el gen: human ... ESR1(2099)

Descripción

Descripción general

Estrogen receptor α (ERα) is a member of the nuclear receptor superfamily.[1] It is also known as ESR1 (estrogen receptor).[2] It is located on human chromosome 6q25.1.[3]
1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole is also termed as PPT. ERα is found in the nuclear and extranuclear sites in principal and inhibitory neurons.[4]

Aplicación

1,3,5-Tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole has been used to cultivate differentiated adipocytes.[5] It is also used in drug treatments[6] and radioimmunoassay (RIA).[7]

Acciones bioquímicas o fisiológicas

Estrogen receptor α (ERα) is involved in immune and inflammatory responses.[8] Aberrations in ESR1 results in Mayer-Rokitansky-Kuster-Hauser syndrome that is associated with the congenital absence of the uterus and the upper two-thirds of the vagina.[9]

PPT is a specific estrogen receptor α (ERα) agonist.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)