G8761

(±)-Gossypol from cotton seeds

≥95% (HPLC), powder, PAF antagonist/inhibitor

• Sinónimos: (±)-2,2′-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene)
• Fórmula empírica (notación de Hill): C₃₀H₃₀O₈
• Número de CAS: 303-45-7
• Peso molecular: 518.55
• Número MDL: MFCD00017352
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24895349
• NACRES: NA.77

Propiedades

• Nombre del producto: (±)-Gossypol from cotton seeds, ≥95% (HPLC)
• Nivel de calidad: 200
• Ensayo: ≥95% (HPLC)
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C([H])C1=C(C(O)=C(C2=C(C)C=C(C(C(C)C)=C(O)C(O)=C3C([H])=O)C3=C2O)C(C)=C4)C4=C(C(C)C)C(O)=C1O
• InChI: 1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3
• Clave InChI: QBKSWRVVCFFDOT-UHFFFAOYSA-N
• Información sobre el gen: human ... AKR1B1(231) , BAD(572) , BCL2(596) , LDHA(3939) , LDHB(3945) , MCL1(4170)

Descripción

Descripción general

Gossypol is considered as an antifertility agent. It is present in cottonseed as a yellowish pigment. This reactive sesquiterpene aldehyde is present in the family Malvaceae and has a molecular mass of 518.54.[1]

Aplicación

(±)-Gossypol from cotton seeds has been used:

• as a standard to quantify the gossypol content in the extracts of leaves and flower buds[2]
• to study its antifertility effects on spermatogenesis in NMRI mice[1]
• to analyse its impact on human spermatozoa[3]
• to incorporate into the artificial diet for larval rearing[4]

Acciones bioquímicas o fisiológicas

Gossypol is a male antifertility agent and PAF antagonist/inhibitor. Gossypol is a poisonous pigment found in cottonseed and its name is derived from the botanical name of the cotton plant, Gossypium.. Gossypium is extracted from selected hybrid species between two Gossypium species, Gossypium hirsutum and Gossypium barbadens. As a PAF antagonist/inhibitor, Gossypium markedly inhibited the contractile responses of guinea pig lung parenchyma strips stimulated with leukotriene B₄, seukotriene D4, and PAF-acether.

Información de seguridad

• Pictogramas: GHS08,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H302,H360F
• Consejos de prudencia: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Clasificaciones de peligro: Acute Tox. 4 Oral - Repr. 1B
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges