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E7275

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Anti-Ephrin-A4 antibody produced in goat

affinity isolated antibody, lyophilized powder

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About This Item

MDL number:
MFCD02096316
UNSPSC Code:
51111800
NACRES:
NA.41

biological source

goat

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

indirect ELISA: 0.5-1.0 μg/mL
western blot: 0.1-0.2 μg/mL

UniProt accession no.

P52798

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... EFNA4(1945)

General description

By ELISA, the antibody shows approximately 50% cross-reactivity with recombinant human ephrin-A5 and no cross-reactivity with recombinant mouse ephrin-A1, mouse ephrin-A2, human ephrin-A3, mouse ephrin-B1, mouse ephrin-B2, and mouse ephrin B3.

Immunogen

recombinant human ephrin-A4, extracellular domain, expressed in NSO cells.

Biochem/physiol Actions

Ephrin A4 binds to EPH receptor A4, a protein-tyrosine kinase family that belongs to the ephrin receptor subfamily. The ephrin-A and ephrin-B ligands and regulate developmental events, particularly those of the nervous system. EphrinA4 regulates the axonal growth, astrocyte reactivity and neuroinflammation in experimental autoimmune encephalomyelitis. High expression of EphA4 receptor correlates with tumor progression, invasion and metastasis of gastric cancer and is a suitable prognostic marker.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

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Storage Class

10 - Combustible liquids

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Kathryn M Munro et al.
PloS one, 8(2), e55948-e55948 (2013-02-08)
The EphA4 receptor tyrosine kinase is a major regulator of axonal growth and astrocyte reactivity and is a possible inflammatory mediator. Given that multiple sclerosis (MS) is primarily an inflammatory demyelinating disease and in mouse models of MS, such as
Kohji Miyazaki et al.
BMC clinical pathology, 13(1), 19-19 (2013-06-07)
Erythropoietin-producing hepatocellular (Eph) receptor, consisting of a family of receptor tyrosine kinases, plays critical roles in tumour development and is considered an attractive target for cancer therapy. Tumour samples were obtained from 222 patients with gastric adenocarcinoma who underwent gastrectomy.
Manish Tandon et al.
Expert opinion on therapeutic targets, 15(1), 31-51 (2010-12-15)
High mortality rates with cancers warrant further development of earlier diagnostics and better treatment strategies. Membrane-bound erythropoietin-producing hepatocellular receptor tyrosine kinase class A2 (EphA2) is overexpressed in breast, prostate, urinary bladder, skin, lung, ovary and brain cancers. EphA2 overexpression in

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