E6657

Eplerenone

≥98% (HPLC)

• Sinónimos: 9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, methyl ester, Cgp 30083, Eplerenone [USAN], Epoxymexrenone, HSDB 7522, Inspra, Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha,11alpha,17alpha)-, SC-66110
• Fórmula empírica (notación de Hill): C₂₄H₃₀O₆
• Número de CAS: 107724-20-9
• Peso molecular: 414.49
• Número MDL: MFCD05662207
• Código UNSPSC: 51111800
• ID de la sustancia en PubChem: 329798999
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to beige
• solubilidad: DMSO: 2 mg/mL, clear (warmed); H₂O: insoluble
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O1[C@]32[C@H]1C[C@@]4([C@@]6(OC(=O)CC6)CC[C@H]4[C@@H]3[C@@H](CC5=CC(=O)CC[C@@]52C)C(=O)OC)C
• InChI: 1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1
• Clave InChI: JUKPWJGBANNWMW-VWBFHTRKSA-N
• Información sobre el gen: human ... NR3C2(4306)

Descripción

Descripción general

Eplerenone is an aldosterone blocker, which particularly blocks mineralocorticoid receptor. It reduces cardiovascular risk in patients following acute myocardial infarction.[1] Eplerenone is used for treating hypertension and central serous retinopathy.[2][3] It exhibits potassium sparing diuretic effect.[4]

Aplicación

Eplerenone has been used in quantitative real time (RT-qPCR) or western blotting assays.[5]

Acciones bioquímicas o fisiológicas

Eplerenone is an aldosterone antagonist more specific for the mineralocorticoid receptor than spironolactone (S3378), having lower affinity for progesterone, androgen, and glucocorticoid receptors.

Eplerenone is an aldosterone antagonist.

Características y beneficios

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)