E3145
3-Ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene
≥90%
Sinónimos:
NOC-12
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Fórmula empírica (notación de Hill):
C6H16N4O2
Número CAS:
Peso molecular:
176.22
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥90%
Quality level:
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Servicio técnico
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Permítanos ayudarleQuality Level
assay
≥90%
storage temp.
−20°C
SMILES string
CCNCCN(CC)\[N+]([O-])=N\O
InChI
1S/C6H16N4O2/c1-3-7-5-6-9(4-2)10(12)8-11/h7,11H,3-6H2,1-2H3/b10-8-
InChI key
DPKCLDSTXVCYSN-NTMALXAHSA-N
General description
3-Ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene (NOC12) is a donor of nitric oxide (NO). It has a long half-life of 327 minutes.[1]
Application
3-Ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene has been used as nitric oxide (NO) donor to study its effects on the isolated trachea preparations from control and ovalbumin-sensitized guinea pigs in vitro.[2] It has also been used as a NO-releasing substance to study its effects on the body contractions patterns of Tethya wilhelma.[3]
Biochem/physiol Actions
3-Ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene (NOC12) liberates nitric oxide (NO) without the use of cofactors or enzymes and the formation of hazardous metabolites. A low dose of NOC12 protects astrocytes from reperfusion injury via a cyclic guanosine monophosphate (cGMP) signal. Higher dosages of NOC12 aggravates reperfusion damage through a cyclic guanosine monophosphate (cGMP)-independent mechanism.[1]
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Este artículo | ||
|---|---|---|
| assay ≥90% | assay - | assay 98% |
| Quality Level 200 | Quality Level - | Quality Level 100 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. - |
signalword
Danger
hcodes
Hazard Classifications
Self-react. C
Clase de almacenamiento
5.2 - Organic peroxides and self-reacting hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Artículos
Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.
Ahmet Parlak et al.
Experimental lung research, 38(8), 420-426 (2012-10-04)
Asthma is a chronic inflammatory disease in which cell components play important roles. We aimed to evaluate the effects of NO/cGMP cleavage at trachea preparations isolated from ovalbumin-sensitized guinea pigs in vitro. Trachea rings were exposed to 3-ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene (NOC-12), (±)-(E)-4-ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide
Kazuhiro Takuma et al.
Japanese journal of pharmacology, 89(1), 64-71 (2002-06-27)
We examined the effect of 3-ethyl-3-(ethylaminoethyl)-1-hydroxy-2-oxo-1-triazene (NOC12), a nitric oxide (NO) donor, on apoptosis in cultured astrocytes. Reperfusion after hydrogen peroxide (H2O2) exposure caused a decrease in cell viability, loss of mitochondrial membrane potential, caspase-3 activation, DNA ladder formation, and
Kornelia Ellwanger et al.
Frontiers in zoology, 3, 7-7 (2006-04-29)
Sponges (Porifera) are nerve- and muscleless metazoa, but display coordinated motor reactions. Therefore, they represent a valuable phylum to investigate coordination systems, which evolved in a hypothetical Urmetazoon prior to the central nervous system (CNS) of later metazoa. We have
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| E3145-10MG | 04061833261538 |