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Merck
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Documentos

D8190

Sigma-Aldrich

3′,4′-Dichlorobenzamil hydrochloride

>98% (HPLC)

Sinónimos:

L-594,881

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About This Item

Fórmula empírica (notación de Hill):
C13H12N7OCl3 · HCl
Número de CAS:
928621-15-2
Peso molecular:
425.10
MDL number:
MFCD03839362
UNSPSC Code:
12352200
PubChem Substance ID:
24278390
NACRES:
NA.77

assay

>98% (HPLC)

form

solid

color

yellow

solubility

DMSO: soluble 30 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

NC1=NC(N)=C(Cl)N=C1C(NC(NCC2=CC(Cl)=C(Cl)C=C2)=N)=O.Cl

InChI

1S/C13H12Cl3N7O.ClH/c14-6-2-1-5(3-7(6)15)4-20-13(19)23-12(24)8-10(17)22-11(18)9(16)21-8;/h1-3H,4H2,(H4,17,18,22)(H3,19,20,23,24);1H

InChI key

LPHAOBPPRPXQLQ-UHFFFAOYSA-N

Biochem/physiol Actions

Inhibits Na+/Ca2+ exchanger, Na+ transport and sarcoplasmic reticulum Ca2+ release channels.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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J P Danaceau et al.
The Journal of general physiology, 115(6), 759-768 (2000-06-01)
Olfactory receptor neurons (ORNs) from the squid, Lolliguncula brevis, respond to the odors l-glutamate or dopamine with increases in internal Ca(2+) concentrations ([Ca(2+)](i)). To directly asses the effects of increasing [Ca(2+)](i) in perforated-patched squid ORNs, we applied 10 mM caffeine
S J Kleene
The Journal of membrane biology, 178(1), 49-54 (2000-11-04)
In vertebrates, cilia on the olfactory receptor neurons have a high density of cyclic-nucleotide-gated (CNG) channels. During transduction of odorous stimuli, cyclic AMP is formed. cAMP gates the CNG channels and this initiates the neuronal depolarization. Here it is shown
G Schultheiss et al.
The Journal of membrane biology, 195(3), 183-196 (2004-01-16)
In the epithelium of rat distal colon the acetylcholine analogue carbachol induces a transient increase of short-circuit current (Isc) via stimulation of cellular K+ conductances. Inhibition of the turnover of inositol-1,4,5-trisphosphate (IP3) by LiCl significantly reduced both the amplitude and
C G Ponte et al.
European journal of pharmacology, 391(1-2), 11-20 (2000-03-18)
Dichlorobenzamil, phenamil and other amiloride analogs (1-100 microM) elicit transient tension in rabbit skinned muscle fibers. Tension requires preloading of Ca(2+) into the sarcoplasmic reticulum, is facilitated by low-[Mg(2+)] solutions, abolished by ruthenium red or by functional disruption of the
G H Liang et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 60(1), 43-50 (2009-05-15)
We investigated the effects of the selective inhibitor of Na(+)/Ca(2+) exchanger (NCX), 2',4'- and 3',4'-dichlorobenzamil (DCB), on large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels in cultured human umbilical vein endothelial cells (HUVECs) and fresh isolated mouse aortic smooth muscle cells (MASMCs) using
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