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Merck

C5366

Chlorisondamine diiodide

≥98% (HPLC), nicotinic acetylcholine receptor antagonist, solid

Sinónimos:

4,5,6,7-Tetrachloro-2,3-dihydro-2-methyl-2-[2-(trimethylammonio)ethyl]-2H-isoindolium diiodide

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10 MG

US$ 247,00

50 MG

US$ 930,00

US$ 247,00

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Fórmula empírica (notación de Hill):
C14H20Cl4I2N2
Número CAS:
96750-66-2
Peso molecular:
611.94
UNSPSC Code:
12352116
PubChem Substance ID:
24724443
NACRES:
NA.77
MDL number:
MFCD01074794
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
200
Storage condition:
protect from light

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Nombre del producto

Chlorisondamine diiodide, ≥98% (HPLC), white, solid

SMILES string

[I-].[I-].C[N+](C)(C)CC[N+]1(C)Cc2c(Cl)c(Cl)c(Cl)c(Cl)c2C1

InChI key

FPNVAOZHQUJJJQ-UHFFFAOYSA-L

InChI

1S/C14H20Cl4N2.2HI/c1-19(2,3)5-6-20(4)7-9-10(8-20)12(16)14(18)13(17)11(9)15;;/h5-8H2,1-4H3;2*1H/q+2;;/p-2

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

white

solubility

H2O: ≥2 mg/mL, DMSO: >20 mg/mL

storage temp.

2-8°C

Quality Level

200

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Este artículo
SML1402A9605N8914
Chlorisondamine diiodide ≥98% (HPLC), white, solid

Sigma-Aldrich

C5366

Chlorisondamine diiodide

TCID ≥98% (HPLC)

Sigma-Aldrich

SML1402

TCID

AC-93253 iodide ≥98% (HPLC)

Sigma-Aldrich

A9605

AC-93253 iodide

NSC308848 ≥98% (HPLC), powder

Sigma-Aldrich

N8914

NSC308848

form

solid

form

powder

form

solid

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: ≥2 mg/mL, DMSO: >20 mg/mL

solubility

DMSO: 5 mg/mL, clear

solubility

DMSO: >10 mg/mL, H2O: insoluble

solubility

DMSO: >20 mg/mL

storage condition

protect from light

storage condition

-

storage condition

desiccated

storage condition

protect from light

color

white

color

white to light brown

color

dark purple

color

yellow

Application

Chlorisondamine diiodide has been used:
  • as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis[1]
  • as an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) induction[2]
  • as a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress[3]

Biochem/physiol Actions

Chlorisondamine diiodide mediates ganglionic and central blockade.[4]
Irreversible, long-lasting nicotinic acetylcholine receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H302,H400

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000258200
0000258199
0000258200
0000258199
0000190009

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T Marenco et al.
British journal of pharmacology, 129(1), 147-155 (2000-02-29)
Chlorisondamine blocks central nicotinic receptors for many weeks via an unknown mechanism. Intracerebroventricular administration of [(3)H]-chlorisondamine in rats results in an anatomically restricted and persistent intracellular accumulation of radioactivity. The initial aim of the present study was to test whether
T Mori et al.
Molecular pharmacology, 59(4), 732-743 (2001-03-22)
Inhalational general anesthetics have recently been shown to inhibit neuronal nicotinic acetylcholine (ACh) receptors (nnAChRs) expressed in Xenopus laevis oocytes and in molluscan neurons. However, drug actions on these systems are not necessarily the same as those seen on native
G Costa et al.
Brain research, 888(2), 336-342 (2001-01-11)
While the work of several groups has shown the neuroprotective effects of nicotine in vitro, evidences for the same effects in vivo are controversial, mainly regarding neuroprotection in experimental models of Parkinson's disease. In this context, we investigated the capability
Jibran Y Khokhar et al.
Brain research, 1348, 1-9 (2010-07-06)
CYP2B is a drug-metabolizing enzyme expressed in the liver and brain that metabolizes a variety of centrally acting drugs (e.g. propofol, bupropion and nicotine), endogenous neurochemicals (e.g. serotonin and testosterone) and toxins (e.g. chlorpyrifos). Human CYP2B6 is found at higher
Colin S Cunningham et al.
Pharmacology, biochemistry, and behavior, 179, 27-33 (2019-02-10)
Mecamylamine is a non-competitive nicotinic acetylcholine receptor (nAChR) antagonist that has been prescribed for hypertension and as an off-label smoking cessation aid. Here, we examined pharmacological mechanisms underlying the interoceptive effects (i.e., discriminative stimulus effects) of mecamylamine (5.6 mg/kg s.c.)
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