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C2743
Cytochalasin B from Drechslera dematioidea
Ready Made Solution, 10 mg/mL in DMSO
Sinónimos:
Phomin
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200 μL
US$ 196,00
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200 μL
US$ 196,00
About This Item
Fórmula empírica (notación de Hill):
C29H37NO5
Número de CAS:
Peso molecular:
479.61
Beilstein:
1096207
Número MDL:
Código UNSPSC:
51102829
ID de la sustancia en PubChem:
NACRES:
NA.85
Productos recomendados
Nivel de calidad
Formulario
solution
concentración
10 mg/mL in DMSO
espectro de actividad antibiótica
fungi
Modo de acción
cell membrane | interferes
temp. de almacenamiento
−20°C
cadena SMILES
C[C@@H]1CCC[C@@H](O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O
InChI
1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1
Clave InChI
GBOGMAARMMDZGR-TYHYBEHESA-N
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Aplicación
Cytochalasin B from Drechslera dematioidea has been used:
- to block cytokinesis, to obtain binucleated cells[1]
- as a specific glucose transporter inhibitor[2]
- to inhibit glucose transport by class I and III GLUTs to determine the 50% inhibitory concentration (IC50) in HCMV-infected and mock-infected cells[3]
Acciones bioquímicas o fisiológicas
Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.
Cytochalasin B can prevent cytoplasmic division without affecting nuclear division.[7]
One of a group of fungal metabolites that interfere with a wide variety of cellular movements. Useful tool for characterizing some of the polymerization properties of actin, and in studies on cytokinesis. Probe for the two hexose-transport systems in rat L6 myoblasts.
Otras notas
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 2 Inhalation - Acute Tox. 4 Oral
Código de clase de almacenamiento
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
185.0 °F - closed cup - Solvent
Punto de inflamabilidad (°C)
85 °C - closed cup - Solvent
Equipo de protección personal
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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What is the Department of Transportation shipping information for this product?
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Is Product C2743, Cytochalasin B, cell culture grade?
1 answer-
The product has been sterile filtered, but it has not been cell culture tested by Sigma.
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How does the storage temperature relate to shipping conditions?
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The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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I have a solution of Product C2743, Cytochalasin B, in DMSO. Is the DMSO toxic to cultured cells?
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At a low enough concentration, the DMSO should not hurt the cells. The final concentration of DMSO in the aqueous working medium typically should not exceed 0.1% because higher DMSO concentrations can adversely affect many cultured cells. Dilute the product in the appropriate aqueous medium to provide a physiologically acceptable final concentration.
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