A8986

Alexidine dihydrochloride

≥95% (HPLC)

• Sinónimos: 1,1′-Hexamethylene-bis(5-[2-ethylhexyl]biguanide)
• Fórmula empírica (notación de Hill): C₂₆H₅₆N₁₀ · 2HCl
• Número de CAS: 1715-30-6
• Peso molecular: 581.71
• Número CE: 216-994-6
• Número MDL: MFCD00082369
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329771026
• NACRES: NA.77

Propiedades

• Ensayo: ≥95% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated
• color: white to off-white
• solubilidad: DMSO: ≥10 mg/mL
• temp. de almacenamiento: −20°C
• cadena SMILES: Cl.Cl.CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC
• InChI: 1S/C26H56N10.2ClH/c1-5-9-15-21(7-3)19-33-25(29)35-23(27)31-17-13-11-12-14-18-32-24(28)36-26(30)34-20-22(8-4)16-10-6-2;;/h21-22H,5-20H2,1-4H3,(H5,27,29,31,33,35)(H5,28,30,32,34,36);2*1H
• Clave InChI: BRJJFBHTDVWTCJ-UHFFFAOYSA-N

Descripción

Aplicación

Alexidine dihydrochloride has been used:

• as an antiseptic to study its antimicrobial activity in saliva-derived microcosm biofilms[1]
• as a protein tyrosine phosphatase localized to the mitochondrion 1 (PTPMT1)-specific inhibitor to study its effects on spare respiratory capacity and viability of CD8⁺ T cells[2]
• as a PTPMT1 inhibitor to study its antiviral effect on  human cytomegalovirus (HCMV) replication in HCMV-infected human foreskin fibroblast (HFF) cells[3]

Acciones bioquímicas o fisiológicas

Alexidine dihydrochloride is a bisbiguanide compound. It has been studied in the treatment of head and neck cancer.[4] Alexidine dihydrochloride also exhibits antibiofilm and antifungal activity against several fungal species. It causes mitochondrial apoptosis in mammalian cells due to its anti-cancer activity.[5] Alexidine dihydrochloride is a component of oral disinfectant and contact lens solution.[6]

Alexidine dihydrochloride is a potent and selective PTPMT1 (Protein Tyrosine Phosphatase Localized to the Mitochondrion 1) inhibitor. Alexidine increases insulin secretion by isolated rat pancreatic islets.

Características y beneficios

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable