A4888

Anfotericina B from Streptomyces sp.

~80% (HPLC), powder

• Sinónimos: Fungizona
• Fórmula empírica (notación de Hill): C₄₇H₇₃NO₁₇
• Número de CAS: 1397-89-3
• Peso molecular: 924.08
• Beilstein: 78342
• Número CE: 215-742-2
• Número MDL: MFCD00877763
• Código UNSPSC: 51102829
• ID de la sustancia en PubChem: 57653841
• NACRES: NA.85

Propiedades

• origen biológico: Streptomyces sp.
• Nivel de calidad: 300
• Ensayo: ~80% (HPLC)
• Formulario: powder
• color: yellow to orange
• solubilidad: DMF: 2-4 mg/mL; DMSO: 30-40 mg/mL; H₂O: insoluble; water: insoluble
• espectro de actividad antibiótica: fungi; yeast
• Modo de acción: cell membrane | interferes
• temp. de almacenamiento: 2-8°C
• cadena SMILES: C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@](O)(C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\2)C[C@H](O)[C@H]3C(O)=O)[C@@H](O)[C@@H](N)[C@@H]1O
• InChI: 1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
• Clave InChI: APKFDSVGJQXUKY-INPOYWNPSA-N

Descripción

Descripción general

Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. and has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes.

Aplicación

Amphotericin B is used to study the affects of the influx of calcium on antifungal activity, [1] and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers [2][3]. It is also commonly used in tissue culture as an antifungal supplement.
Amphotericin B from Streptomyces sp. has been used-

• for amphotericin perforated patch technique[4]
• as a reference antifungal drug during MIC (minimum inhibitory concentration) agar dilution assay[5][6][7]
• as a component of Arcobacter selective isolation broth[8]

Acciones bioquímicas o fisiológicas

La anfotericina B se une a los esteroles formando poros en la membrana y provocando la salida de moléculas pequeñas. La máxima eficacia del producto es contra hongos y levaduras.

Mode of Action: Amphotericin B binds to sterols, forming pores in the membrane, and causing small molecules to leak out.

Antimicrobial spectrum: Includes fungi and yeast

Características y beneficios

High quality antibiotic suitable for mulitple research applications

Nota de preparación

Amphotericin B is insoluble in water at pH 6 to 7, but soluble in water at pH 2 or 11. It is soluble in DMSO (30-40 mg/mL) and in dimethylformamide (2-4 mg/mL). Aqueous solutions cannot be sterile filtered due to poor solubility.

Amphotericin B remains active for 3 days in culture at 37°C. At -20°C, and with protection from air and light, the product remains active for 5 years.

Almacenamiento y estabilidad

Tightly closed. Dry. Keep in a well -ventilated place. Keep locked up or in an area accessible

Otras notas

For additional information on our range of Biochemicals, please complete this form.

Keep container tightly closed in a dry and well-ventilated place. Product is sensitive to light and moisture. Keep in a dry place.

Información de seguridad

• Pictogramas: GHS08
• Palabra de señalización: Danger
• Frases de peligro: H372
• Consejos de prudencia: P260 - P264 - P270 - P314 - P501
• Clasificaciones de peligro: STOT RE 1
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves