Uridine 5dATP-diphosphogalactose (UDP-Gal) is a sugar-nucleotide substrate of galactosyltransferase(s) involved in the addition of galatose (galactosylation) molecules to N-linked and O-linked oligosaccharides and glycerolipids. UDP-Gal and its analogues are used to study the distribution, specificity and kinetics of galactosyltransferase(s).
Structural analogues and mimics of the natural sugar-nucleotide UDP-galactose (UDP-Gal) are sought after as chemical tools for glycobiology and drug discovery. We have recently developed a novel class of galactosyltransferase (GalT) inhibitors derived from UDP-Gal, bearing an additional substituent at
Subcellular localization of UDP-GlcNAc, UDP-Gal and SLC35B4 transporters.
Trends in plant science, 16(2), 98-107 (2010-12-15)
Galactoglycerolipids are the predominant lipid building blocks of chloroplast membranes and are essential for plant growth. Plant chloroplasts harbor a constitutive set of UDP-Gal-dependent lipid galactosyltransferases that are responsible for the bulk of galactoglycerolipid biosynthesis. A set of paralogs is
Development of IgA nephropathy-like disease with high serum IgA levels and increased proportion of polymeric IgA in β-1,4-galactosyltransferase-deficient mice.
Nishie T, Miyaishi O, Azuma H, et al.
The American Journal of Pathology, 157, 125-128 (2007)
Biotechnology and bioengineering, 75(2), 239-251 (2001-09-06)
Variable N-glycosylation at Asn(297) in the Fc region of recombinant therapeutic immunoglobulin G (IgG) molecules, specifically terminal galactosylation and sialylation, may affect both pharmacokinetic behavior and effector functions of recombinant therapeutic antibodies. We investigated the hypothesis that IgG Fc glycosylation
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