This product may be stored at room temperature.
83702
Rhodamine 123
BioReagent, for fluorescence, ≥85% (HPLC)
Sinónimos:
2-(6-Amino-3-imino-3H-xanthen-9-yl)benzoic acid methyl ester
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10 MG
US$ 141,00
50 MG
US$ 500,00
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10 MG
US$ 141,00
50 MG
US$ 500,00
About This Item
Fórmula lineal:
C21H17ClN2O3
Número de CAS:
Peso molecular:
380.82
Beilstein:
6030951
Número CE:
Número MDL:
Código UNSPSC:
12352116
ID de la sustancia en PubChem:
NACRES:
NA.32
Productos recomendados
grado
for fluorescence
Línea del producto
BioReagent
Ensayo
≥85% (HPLC)
Formulario
powder
impurezas
≤10% water
solubilidad
ethanol: 20 mg/mL, clear, red
idoneidad
in accordance for fluorescence
suitable for fluorescence
cadena SMILES
Cl[H].COC(=O)c1ccccc1C2=C3C=CC(=N)C=C3Oc4cc(N)ccc24
InChI
1S/C21H16N2O3.ClH/c1-25-21(24)15-5-3-2-4-14(15)20-16-8-6-12(22)10-18(16)26-19-11-13(23)7-9-17(19)20;/h2-11,22H,23H2,1H3;1H
Clave InChI
MYFATKRONKHHQL-UHFFFAOYSA-N
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Descripción general
Rhodamine 123 is a fluorescent dye.[1]
Aplicación
Rhodamine 123 has been used:
- as a substrate for P-glycoprotein (P-gp) to read out functional transporter activity in fluorescent accumulation assays[2]
- to label the cells for estimating the P-gp expression by flow cytometry[1]
- in transport studies, was added to the apical to basolateral (AB-transport) or basolateral to apical (BA-transport)[3]
- the detection of mitochondrial membrane potential (ΔΨm)[4]
Acciones bioquímicas o fisiológicas
Fluorescent dye most commonly used in flow cytometry as functional reporter for Pgp. Functional assays for MDR proteins are better prognostic indicators in cancer therapy than levels of MDR protein expression. Rh 123 can be used in multiparameter analyses without fluorescence interference in combination with common protein labeling dyes such as PE-Cy5 and AMCA (7-amino-4-methylcoumarin-3-acetic acid). Recent reports indicate Rh 123 may also be a substrate of MRP1.
Rhodamine 123 is usually used as a functional reporter for P-glycoprotein (P-gp) in flow cytometry.[1]
Otras notas
Supravital mitochondrial-specific dye[5]
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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The use of the supravital mitochondrial-specific dye Rhodamine 123 (Rh 123) in combination with flow cytometry permits the monitoring of the changes in the mitochondrial transmembrane potential, reflecting the overall mitochondrial activity of the living cell. While this probe appears
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Which is the storage conditions recommend for this product?
1 answer-
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What are the excitation and emission wavelengths for Rhodamine 123 (Product Nos. 83702 and R8004)?
1 answer-
Using ethanol as the solvent, the excitation maximum is 511 nm and the emission maximum is 534 nm. The recommended excitation and emission wavelengths in PBS are 488 and 515-575 nm, respectively.
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Why would one select Rhodamine 123 (Product Nos. 83702 and R8004) instead of other rhodamine compounds?
1 answer-
Due to is comparatively low toxicity, Rhodamine 123 is the dye of choice for visualizing mitochondria or for cell viability measurements.
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What is the solubility of Rhodamine 123, (Product Nos. 83702 and R8004)?
1 answer-
Rhodamine 123 is soluble in ethanol at 20 mg/mL, and has been reported soluble in ether, various fats and lipids, and has limited solubility in water (no concentration given).
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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