The stability of this product in solution is not determined. However, similar product F3506 states that solutions of N-Formyl-Met-Leu-Phe can be stored, in aliquots, at -20°C for at least six months.
47729
N-Formyl-Met-Leu-Phe
≥99.0% (TLC), BioXtra
Sinónimos:
Chemotactic peptide, N-Formyl-L-methionyl-L-leucyl-L-phenylalanine, fMLF, fMLP (misnomer but widely used)
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10 MG
US$ 219,00
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10 MG
US$ 219,00
About This Item
Fórmula empírica (notación de Hill):
C21H31N3O5S
Número de CAS:
Peso molecular:
437.55
Beilstein:
2315783
Número MDL:
Código UNSPSC:
12352209
ID de la sustancia en PubChem:
NACRES:
NA.26
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Nombre del producto
N-Formyl-Met-Leu-Phe, BioXtra, ≥99.0% (TLC)
Línea del producto
BioXtra
Ensayo
≥99.0% (TLC)
Formulario
powder
color
white
solubilidad
DMF: 50 mg/mL, clear, colorless
aplicaciones
cell analysis
temp. de almacenamiento
2-8°C
cadena SMILES
CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
InChI
1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1
Clave InChI
PRQROPMIIGLWRP-BZSNNMDCSA-N
Información sobre el gen
human ... FPR1(2357)
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Amino Acid Sequence
NFor-Met-Leu-Phe
Aplicación
1. 4th and 5th applications do not have access
2. 3rd application is not relevant
2. 3rd application is not relevant
Acciones bioquímicas o fisiológicas
N-Formyl-Met-Leu-Phe is a potent chemotactic peptide and formyl peptide receptor (FPR) agonist that induces a metabolic burst in macrophages accompanied by an increase in respiratory rate, secretion of lysosomal enzymes, and production of superoxide anion.
Potent chemotactic peptide. Induces a metabolic burst in macrophages accompanied by an increase in respiratory rate, secretion of lysosomal enzymes, and production of superoxide anion.
Envase
Bottomless glass bottle. Contents are inside inserted fused cone.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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C Dahlgren et al.
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A D-methionine-containing peptide, Trp-Lys-Tyr-Met-Val-D-Met-NH(2) (WKYMVm), featuring a unique receptor specificity was investigated with respect to its ability to activate neutrophil effector functions. The peptide was found to be more potent than the N-formylated peptide N-formyl-Met-Leu-Phe (fMLF) at inducing neutrophil chemotaxis
Off-pump coronary artery bypass surgery induces prolonged alterations to host neutrophil physiology.
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Karama Makni-Maalej et al.
Journal of immunology (Baltimore, Md. : 1950), 189(9), 4657-4665 (2012-09-25)
Superoxide anion production by the neutrophil NADPH oxidase plays a key role in host defense; however, excessive superoxide production is believed to participate to inflammatory reactions. Neutrophils express several TLR that recognize a variety of microbial motifs or agonists. The
Loïc Rolas et al.
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Cirrhosis is commonly accompanied by impaired defense functions of polymorphonuclear leucocytes (PMNs), increased patient susceptibility to infections, and hepatocellular carcinoma (HCC). PMN antimicrobial activity is dependent on a massive production of reactive oxygen species (ROS) by nicotinamide adenine dinucleotide phosphate
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Nature immunology, 14(1), 34-40 (2012-11-13)
Acute inflammatory responses are important in host defense, whereas dysregulated inflammation results in life-threatening complications. Here we found that paired immunoglobulin-like type 2 receptor alpha (PILRα), an inhibitory receptor containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs), negatively regulated neutrophil infiltration during
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How long can this product be stored at -20 when reconstituted in DMSO?
1 answer-
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What is the solubility of the product 47729, N-Formyl-Met-Leu-Phe?
1 answer-
Product is soluble in water (partly), methanol, DMSO (4 mg/ml), ethanol (2 mg/ml), and DMF (Dimethylformamide) (50 mg/ml).
Helpful?
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Can this product be dissolved in DMSO?
1 answer-
Yes, this product can be solubilized in DMSO. The exact concentration at which it may be solubilized is not determined. However, several sources state that it is soluble in DMSO at 30 mg/mL.
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