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SMB00961

Sigma-Aldrich

Amitriptyline N-oxide

Sinónimos:

Amitriptylinoxide

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About This Item

Fórmula empírica (notación de Hill):
C20H23NO
Número de CAS:
4317-14-0
Peso molecular:
293.40
UNSPSC Code:
12352119
NACRES:
NA.77

biological source

synthetic

Quality Level

100

grade

research grade

assay

≥95%

form

solid

storage condition

under inert gas

technique(s)

HPLC: suitable

color

white to off-white

storage temp.

−20°C

InChI

1S/C20H23NO/c1-21(2,22)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3

InChI key

ZPMKQFOGINQDAM-UHFFFAOYSA-N

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General description

Amitriptyline N-oxide is the N-oxidation metabolite of the antidepressant amitriptyline

Application

Metabolomics research

Other Notes

For additional information on our range of Biochemicals, please complete this form.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
SLCH9846

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Thomas Altendorfer-Kroath et al.
Journal of neuroscience methods, 311, 394-401 (2018-09-30)
Assessment of drug concentration in the brain interstitial fluid (ISF) is crucial for development of brain active drugs, which are mainly small, lipophilic substances able to cross the blood-brain barrier (BBB). We aimed to compare the applicability of cerebral Open
Judith M Kampa et al.
Toxicology letters, 325, 43-50 (2020-02-25)
As a consequence of the detoxification process, drugs and drug related metabolites can accumulate in the liver, resulting in drug induced liver injury (DILI), which is the major cause for dose limitation. Amitriptyline, a commonly used tricyclic anti-depressant, is known
Ursula Breyer-Pfaff
Drug metabolism reviews, 36(3-4), 723-746 (2004-11-24)
Amitriptyline (AT), the most widely used tricyclic antidepressant, undergoes oxidative metabolism in the side chain with production of the secondary amine nortriptyline (NT), a primary amine, and the N-oxide amitriptylinoxide (AT-NO); in addition, direct conjugation leads to a quaternary ammonium-linked

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