Journal of biomedical materials research. Part A, 99(3), 410-417 (2011-10-25)
Urethane polymers (PU) have been prepared from low-molecular weight polylactic acid (PLA) and hexamethylene diisocyanate (HMDI) using polydimethylsiloxane (PDMS) as a chain extender. These formed the supporting polymeric matrix of curcumin-containing PU membranes which were prepared using a solvent evaporation
American journal of obstetrics and gynecology, 192(5), 1643-1648 (2005-05-20)
The purpose of this study was to examine the histopathologic changes of HMDI (Hexamethylene di-isocyanate) cross-linked porcine dermis grafts used for suburethral sling surgery. Twelve patients underwent reoperation with graft removal for urinary retention or recurrent stress urinary incontinence after
Toxicology and applied pharmacology, 78(3), 445-450 (1985-05-01)
Groups of English smooth-haired guinea pigs and BALB/cBy mice were exposed to dicyclohexylmethane-4,4'-diisocyanate (HMDI) and picryl chloride (PiCl) by topical exposure. Guinea pigs were challenged 7 days later by patch testing and responses graded at 24 hr. Application of high
Skin sensitization with chemical allergens is associated with the activation and proliferation of lymphocytes in lymph nodes draining the site of exposure. As lymphocyte activation is regulated by the action of cytokines, we have investigated the nature and kinetics of
Isocyanates are widely used in the manufacturing of rigid and flexible foams, fibers, and coatings such as paints, varnishes, and elastomers but are rarely reported as contact sensitizers. The aliphatic diisocyanate dicyclohexylmethane-4,4'-diisocyanate (DMDI) is known to be a strong cutaneous
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