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Merck

05292

Sigma-Aldrich

Spermidine 0.1 M solution

Spermidine 0.1 M solution
1 of 1 reviewers received a sample product or took part in a promotion

Sinónimos:

Spermidine solution, Additive Screening Solution 30/Kit-No 78374

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About This Item

Número de CAS:
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.32
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Nivel de calidad

densidad

1.00 g/mL at 20 °C

temp. de almacenamiento

2-8°C

cadena SMILES

NCCCCNCCCN

InChI

1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2

Clave InChI

ATHGHQPFGPMSJY-UHFFFAOYSA-N

Información sobre el gen

mouse ... Odc1(18263)
rat ... Ppm1a(24666)

Acciones bioquímicas o fisiológicas

Spermidine is a naturally occurring polyamine. It is associated with various cellular functions. It is responsible for the condensation and aggregation of DNA in aqueous solution.[1][2] Spermidine is known to extend lifespan via epigenetic modifications, induction of cell death and inhibition of necrosis.[3]
Spermidine 0.1M solution is an additive screening solution of Additive Screening Kit. Additive Screen kit is designed to allow rapid and convenient evaluation of additives and their ability to influence the crystallization of the sample. The Additive Kit provides a tool for refining crystallization conditions.

Pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Eye Irrit. 2 - Skin Irrit. 2

Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Faceshields, Gloves, Goggles


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Induction of autophagy by spermidine promotes longevity.
Eisenberg T et al.
Nature Cell Biology, 11, 1305-1305 (2009)
Satyanarayana U
Biochemistry (2014)
Marjorie Catala et al.
Bio-protocol, 10(12), e3646-e3646 (2021-03-05)
Transfer RNAs (tRNAs) are heavily decorated with post-transcriptional modifications during their biosynthesis. To fulfil their functions within cells, tRNAs undergo a tightly controlled biogenesis process leading to the formation of mature tRNAs. In addition, functions of tRNAs are often modulated
53rd National Meeting of the Italian Society of Biochemistry and Molecular Biology (SIB) and National Meeting of Chemistry of Biological Systems ? Italian Chemical Society (SCI - Section CSB) (2008)
Stephana Carelli et al.
Experimental dermatology, 21(12), 953-955 (2012-10-24)
Hair follicle (HF) regression is characterized by the activation of apoptosis in HF cells. Dermal papilla cells play a leading role in the regulation of HF development and cycling. Human follicular dermal papilla cells (HFDPC) were used to investigate the

Questions

1–2 of 2 Questions  
  1. What is the pH of this spermidine solution please?

    1 answer
    1. The pH for this spermidine solution is not determined.

      Helpful?

  2. What is the solvent for this product? Is there an additive that allows it to remain stable at 4 degrees for an extended period of time?

    1 answer
    1. This product is a 0.1 M solution of spermidine in water. There is no preservative added. The material is sterile filtered and dispensed to autoclaved bottles. Thus microbial contamination is eliminated. Amines are oxidized by contact with air/oxygen. Stability will be maintained if the oxygen-free water is used for dilution and vial headspace is cleared of oxygen using an inert gas such as argon or nitrogen.

      Helpful?

Reviews

1 of 1 reviewers received a sample product or took part in a promotion

Active Filters

    • Review 1
    • Votes 0
    5 out of 5 stars.

    Dr.

    very good, my experiment got very good results_ thanks

    Helpful?

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