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MABT42

Sigma-Aldrich

Anti-Integrin beta-2 (CD18) Antibody, clone M18/2

clone M18/2, from rat

Sinónimos:

integrin, beta 2 (complement component 3 receptor 3 and 4 subunit), integrin beta chain, beta 2, complement receptor C3 beta-subunit, leukocyte cell adhesion molecule CD18, integrin beta-2, Complement receptor C3 subunit beta, Cell surface adhesion glyco

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rat

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

M18/2, monoclonal

species reactivity

mouse

technique(s)

flow cytometry: suitable
immunoprecipitation (IP): suitable

isotype

IgG2aκ

NCBI accession no.

NP_032430

UniProt accession no.

P11835

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Itgb2(16414)

General description

Integrin beta-2, also known as CD18, is an adhesion receptor in neutrophils that interacts with cytohesin-1 intracellularly. Integrin beta is instrumental in activation-dependent adhesion and adhesion-dependent signaling. Expression of integrin beta-2 has a positive correlation with patient survival from malignant B cell lymphoma.

Immunogen

Whole B10 mouse spleen cells enriched with T-cells.

Application

Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP (Sanchez-Madrid, F., et al. (1983). J. ExP. MED. 158:586-602).

Inhibition Analysis: A previous lot of this antibody was shown to inhibit lymphoma metastasis (Zahalka, M. A. et al. (1993) J. Immunol. 150, 4466).
This Anti-Integrin beta-2 (CD18) Antibody, clone M18/2 is validated for use in FC, IP for the detection of Integrin beta-2 (CD18).

Quality

Evaluated by Flow Cytometry in mouse EL4 cells.

Flow Cytometry Analysis: 10 µg of this antibody detected Integrin beta-2 in mouse EL4 cells.

Target description

85 kDa calculated

Physical form

Format: Purified

Analysis Note

Control
Mouse EL4 cells

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Kimberly F Young et al.
Journal of neuroinflammation, 18(1), 58-58 (2021-02-24)
Ischemic stroke is an acquired brain injury with gender-dependent outcomes. A persistent obstacle in understanding the sex-specific neuroinflammatory contributions to ischemic brain injury is distinguishing between resident microglia and infiltrating macrophages-both phagocytes-and determining cell population-specific contributions to injury evolution and
Mitra Farnoodian et al.
American journal of physiology. Cell physiology, 311(3), C418-C436 (2016-07-22)
Defects in the outer blood-retinal barrier have significant impact on the pathogenesis of diabetic retinopathy and macular edema. However, the detailed mechanisms involved remain largely unknown. This is, in part, attributed to the lack of suitable animal and cell culture

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