MABT332

Anti-Obscurin Antibody, clone 4A8

clone 4A8, from mouse

• Sinónimos: Obscurin, Obscurin-RhoGEF, Obscurin-myosin light chain kinase, Obscurin-MLCK
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• forma del anticuerpo: purified antibody
• tipo de anticuerpo: primary antibodies
• clon: 4A8, monoclonal
• reactividad de especies: rat
• reactividad de especies (predicha por homología): human (based on 100% sequence homology)
• técnicas: immunohistochemistry: suitable (paraffin); western blot: suitable
• isotipo: IgG1κ
• Nº de acceso NCBI: NP_001092093
• Nº de acceso UniProt: Q5VST9
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... OBSCN(84033)

Descripción

Descripción general

Obscurin, also known as Obscurin-RhoGEF or Obscurin-myosin light chain kinase, is encoded by the gene name OBSCN. Obscurin is involved in myofibrillogenesis and the assembly of myosin into sarcomeric A bands in striated muscle. Obscurin isoform 3 plus ANK1 isoform Mu17/Ank1.5 may be molecular link between the sarcoplasmic reticulum and myofibrils.

Inmunógeno

GST-tagged recombinant protein corresponding to the N-terminus of human Obscurin.

Aplicación

This Anti-Obscurin antibody is validated for use in WB, IH(P) for the detection of Obscurin.

Western Blotting Analysis: A representative lot detected Obscurin in extracts of adult rat quadriceps tissue lysate (Bowman, A.L., et al. (2007). FEBS Letters. 581:1549-1554).
Immunohistochemistry by fluorescent Analysis: A representative lot detected Isocitrate dehydrogenase in rat muscle tissue at resting stage (Bowman, A.L., et al. (2007). FEBS Letters. 581:1549-1554).

Calidad

Evaluated by Immunohistochemistry in rat skeletal muscle tissue.

Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected Obscurin in rat skeletal muscle tissue.

Descripción de destino

800 kDa calculated

Forma física

Format: Purified

Otras notas

Concentration: Please refer to lot specific datasheet.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable