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MAB395

Sigma-Aldrich

Anti-Myelin Basic Protein Antibody, a.a. 36-50, clone 14

culture supernatant, clone 14, Chemicon®

Sinónimos:

MBP

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rat

Quality Level

antibody form

culture supernatant

antibody product type

primary antibodies

clone

14, monoclonal

species reactivity (predicted by homology)

mammals

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
immunohistochemistry: suitable

isotype

IgG2b

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... MBP(4155)

Specificity

Reacts with a synthetic peptide corresponding to human MBP sequence 36-50 as well as intact human MBP. Numbering of MBP residues is as described by Martenson (1984). Mapped by Geyson method to FFGGDR and RFFGGO region.

Immunogen

Bovine myelin basic protein.
Epitope: a.a. 36-50

Application

Detect Myelin Basic Protein using this Anti-Myelin Basic Protein Antibody, a.a. 36-50, clone 14 validated for use in ELISA, IH.
Immunohistochemistry (frozen sections)

ELISA

This antibody is also expected to work for Western blot. Specific testing has not been performed.

Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Research Sub Category
Neuronal & Glial Markers

Neurochemistry & Neurotrophins

Linkage

Replaces: MAB395

Physical form

Tissue culture supernatant. Liquid containing 0.09% sodium azide.

Storage and Stability

Maintain at -20° in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze-thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Functional screening for compounds that promote remyelination represents a major hurdle in the development of rational therapeutics for multiple sclerosis. Screening for remyelination is problematic, as myelination requires the presence of axons. Standard methods do not resolve cell-autonomous effects and
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Neurobiology of disease, 130, 104489-104489 (2019-06-09)
Sedatives and anesthetics can injure the developing brain. They cause apoptosis of neurons and oligodendrocytes, impair synaptic plasticity, inhibit neurogenesis and trigger long-term neurocognitive deficits. The projected vulnerable period in humans extends from the third trimester of pregnancy to the
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The Journal of biological chemistry, 289(3), 1629-1638 (2013-11-28)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of motor neurons. Here we show that the basic leucine zipper transcription factor NFIL3 (also called E4BP4) confers neuroprotection in models of ALS. NFIL3 is up-regulated in primary
Sharmony B Kelly et al.
Journal of neuroinflammation, 18(1), 189-189 (2021-09-02)
Increased systemic and tissue levels of interleukin (IL)-1β are associated with greater risk of impaired neurodevelopment after birth. In this study, we tested the hypothesis that systemic IL-1 receptor antagonist (Ra) administration would attenuate brain inflammation and injury in near-term

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