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Sigma-Aldrich

QX-314

≥99% (HPLC), lyophilized solid, voltage-sensitive Na+ conductance blocker, Calbiochem®

Sinónimos:

QX-314

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About This Item

Fórmula empírica (notación de Hill):
C16H27BrN2O
Número de CAS:
21306-56-9
Peso molecular:
343.30
MDL number:
MFCD00083182
UNSPSC Code:
12352200
NACRES:
NA.77

product name

QX-314, A quaternary lidocaine derivative, permanently charged, and lipophobic.

Quality Level

100

assay

≥99%

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

solubility

water: 3 mg/mL

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C16H26N2O/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5/h9-11H,6-8,12H2,1-5H3/p+1

InChI key

PYEBKOFMWAMBFV-UHFFFAOYSA-O

General description

A quaternary lidocaine derivative, permanently charged, and lipophobic. A powerful blocker of voltage-sensitive Na+ conductance when applied intracellularly. Suppresses the generation of Na+-dependent spikes from inside the cell membrane, without affecting Ca2+ currents or glutamate-activated currents.

Biochem/physiol Actions

Cell permeable: no
Primary Target
A powerful blocker of voltage-sensitive Na+ conductance
Product does not compete with ATP.
Reversible: no
fully active in neurophysiological testing

Warning

Toxicity: Irritant (B)

Other Notes

Mooney, R. 1992. J. Neurosci.12, 2464.
Regehr, W.G. and Tank, D.W. 1992. J. Neurosci.12, 4202.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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