420294

STAT5 Inhibitor II, IQDMA

The STAT5 Inhibitor II, IQDMA controls the biological activity of STAT5.

• Sinónimos: STAT5 Inhibitor II, IQDMA, N1-(11H-indolo[3,2-c]quinolin-6-yl)-N2,N2-dimethylethane-1,2-diamine
• Fórmula empírica (notación de Hill): C₁₉H₂₀N₄
• Peso molecular: 304.39
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: brown
• solubility: DMSO: 50 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Descripción

General description

A cell-permeable indoloquinoline compound that exhibits anticancer activity and inhibits the growth of A549 lung cancer cells (IC₅₀ = 8 µM), as well as HL-60 (IC₅₀ = 5 µM) and K562 (IC₅₀ = 8 µM) leukemia cells. IQDMA-mediated apoptosis is shown to correlate with a downregulation of STAT5 pathway signaling in HL-60 and K562 cultures, while JNK and p38 signalings are shown to be activated in A549 cells upon IQDMA treatment.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Su, J.C., et al. 2009, Life Sci.85, 505.
Chien, C.M., et al. 2008, Chem-Biol. Intr.176, 40.
Yang, S.H., et al. 2008, J. Biochem. Mol. Tox.22, 396.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable