800810P
Avanti
10:0 DG
1,2-didecanoyl-sn-glycerol, powder
Sinónimos:
DG(10:0/10:0/0:0)
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10 MG
US$ 161,00
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10 MG
US$ 161,00
About This Item
Fórmula empírica (notación de Hill):
C23H44O5
Número de CAS:
Peso molecular:
400.59
Número MDL:
Código UNSPSC:
12352211
NACRES:
NA.25
Productos recomendados
Ensayo
>99% (TLC)
Formulario
powder
envase
pkg of 1 × 10 mg (with screw cap (800810P-10mg))
fabricante / nombre comercial
Avanti Research™ - A Croda Brand 800810P
tipo de lípido
neutral lipids
neutral glycerides
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
cadena SMILES
O([C@H](COC(=O)CCCCCCCCC)CO)C(=O)CCCCCCCCC
InChI
1S/C23H44O5/c1-3-5-7-9-11-13-15-17-22(25)27-20-21(19-24)28-23(26)18-16-14-12-10-8-6-4-2/h21,24H,3-20H2,1-2H3/t21-/m0/s1
Clave InChI
GNSDEDOVXZDMKM-NRFANRHFSA-N
Descripción general
10:0 DG (DDG), also called 1,2-didecanoyl-sn-glycerol, is a substrate for human pancreatic lipase (HPL).[1]
In biochemical signaling, diacylglycerol (DAG) functions as a second messenger signaling lipid, and is a product of the hydrolysis of the phospholipid PIP2 (phosphatidylinositolbisphosphate) by the enzyme phospholipase C (PLC) (a membrane-bound enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). Although inositol trisphosphate (IP3) diffuses into the cytosol, DAG remains within the plasma membrane due to its hydrophobic properties. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, whereas DAG is a physiological activator of protein kinase C (PKC). The production of DAG in the membrane facilitates translocation of PKC from the cytosol to the plasma membrane.[2][3][4][5]
Diacylglycerol mimicks the effects of the tumor-promoting compounds phorbol esters.
Diacylglycerol mimicks the effects of the tumor-promoting compounds phorbol esters.
Aplicación
Envase
5 mL PTFE Vial with Screw Cap (800810P-10mg)
Almacenamiento y estabilidad
Diacylglycerols are conveniently stored in chloroform solutions in glass vials with PTFE-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.
Otras notas
Delivery to cells:
Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.
Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.
Effective concentration:
Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.
Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.
Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.
Información legal
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Código de clase de almacenamiento
11 - Combustible Solids
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Effects of vitamin E and its derivatives on diabetic nephropathy in Rats and identification of diacylglycerol kinase subtype involved in the improvement of diabetic nephropathy
Kakehi T, et al.
Functional Foods in Health and Disease, 7(10), 816-832 (2017)
Importance of chroman ring and tyrosine phosphorylation in the subtype-specific translocation and activation of diacylglycerol kinase alpha by d-alpha-tocopherol
Fukunaga-Takenaka R, et al.
Genes Cells, 10(4), 311-319 (2005)
Chitosan does not inhibit enzymatic action of human pancreatic lipase in Langmuir monolayers of 1, 2-didecanoyl-glycerol (DDG)
Souza AL, et al.
Colloids and Surfaces, B: Biointerfaces, 123, 870-877 (2014)
B R Ganong et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(5), 1184-1188 (1986-03-01)
The specificity of protein kinase C activation by sn-1,2-diacylglycerols and analogues was investigated by using a Triton X-100 mixed micellar assay [Hannun, Y. A., Loomis, C. R. & Bell, R. M. (1985) J. Biol. Chem. 260, 10039-10043]. Analogues containing acyl
J G Ebeling et al.
Proceedings of the National Academy of Sciences of the United States of America, 82(3), 815-819 (1985-02-01)
Activation of cellular protein kinase C appears to be involved in the mechanism by which phorbol diesters induce differentiation of human myeloid leukemia cells (HL-60). Protein kinase C is thought to be physiologically activated by diacylglycerol derived from receptor-mediated phosphatidylinositol
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