700048P
Avanti
24(R/S),25-epoxycholesterol-d6
Avanti Research™ - A Croda Brand
Sinónimos:
26,26,26,27,27,27-hexadeutero-24,25-epoxycholesterol
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About This Item
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description
24(R/S),25-epoxycholesterol-d6
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (700048P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
Categorías relacionadas
General description
24(R/S),25-epoxycholesterol-d6 is a deuterated side-chain substituted oxysterol.
Application
24(R/S),25-epoxycholesterol-d6 has been used as a primary and deuterated surrogate sterol standard in the quantitative analysis of extracted sterol samples from cultured cells and tissues.
Biochem/physiol Actions
24(S),25-epoxycholesterol maintains cholesterol homeostasis. It modulates hepatic cholesterol metabolism in vivo. 24(S),25-epoxycholesterol is synthesized in the mevalonate pathway. It inhibits sterol regulatory element-binding protein (SREBP) activation.
Deuterated sterol plays a vital role in chemical and biochemical research. It is used as a mechanistic tracer to study the role of steroid hormones in the function and modulation of several physiological processes. Deuterated sterol is also used as reference standards for mass spectrometry. 24(R/S),25-epoxycholesterol-d6 is a deuterium labeled sterol.
Packaging
5 mL Amber Glass Screw Cap Vial (700048P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Site-specific synthesis and application of Deuterium-Labeled sterols
Archive for Organic Chemistry (2017)
24 (S), 25-epoxycholesterol: a messenger for cholesterol homeostasis
The International Journal of Biochemistry & Cell Biology, 41(4), 744-747 (2019)
Extraction and analysis of sterols in biological matrices by high performance liquid chromatography electrospray ionization mass spectrometry
Test, 432, 145-170 (2007)
Methods in enzymology, 432, 145-170 (2007-10-24)
We describe the development of a high performance liquid chromatography mass spectrometry (HPLC-MS) method that allows the identification and quantitation of sterols in mammalian cells and tissues. Bulk lipids are extracted from biological samples by a modified Bligh/Dyer procedure in
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