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Merck

700048P

Avanti

24(R/S),25-epoxycholesterol-d6

Avanti Research - A Croda Brand

Sinónimos:

26,26,26,27,27,27-hexadeutero-24,25-epoxycholesterol

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About This Item

Fórmula empírica (notación de Hill):
C27H38O2D6
Número de CAS:
Peso molecular:
406.67
UNSPSC Code:
41116107
NACRES:
NA.25

description

24(R/S),25-epoxycholesterol-d6

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (700048P-1mg)

manufacturer/tradename

Avanti Research - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

Categorías relacionadas

General description

24(R/S),25-epoxycholesterol-d6 is a deuterated side-chain substituted oxysterol.

Application

24(R/S),25-epoxycholesterol-d6 has been used as a primary and deuterated surrogate sterol standard in the quantitative analysis of extracted sterol samples from cultured cells and tissues.

Biochem/physiol Actions

24(S),25-epoxycholesterol maintains cholesterol homeostasis. It modulates hepatic cholesterol metabolism in vivo. 24(S),25-epoxycholesterol is synthesized in the mevalonate pathway. It inhibits sterol regulatory element-binding protein (SREBP) activation.
Deuterated sterol plays a vital role in chemical and biochemical research. It is used as a mechanistic tracer to study the role of steroid hormones in the function and modulation of several physiological processes. Deuterated sterol is also used as reference standards for mass spectrometry. 24(R/S),25-epoxycholesterol-d6 is a deuterium labeled sterol.

Packaging

5 mL Amber Glass Screw Cap Vial (700048P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Site-specific synthesis and application of Deuterium-Labeled sterols
Muchalski H, et al.
Archive for Organic Chemistry (2017)
24 (S), 25-epoxycholesterol: a messenger for cholesterol homeostasis
Brown AJ
The International Journal of Biochemistry & Cell Biology, 41(4), 744-747 (2019)
Extraction and analysis of sterols in biological matrices by high performance liquid chromatography electrospray ionization mass spectrometry
McDonald J, et al.
Test, 432, 145-170 (2007)
Jeffrey G McDonald et al.
Methods in enzymology, 432, 145-170 (2007-10-24)
We describe the development of a high performance liquid chromatography mass spectrometry (HPLC-MS) method that allows the identification and quantitation of sterols in mammalian cells and tissues. Bulk lipids are extracted from biological samples by a modified Bligh/Dyer procedure in

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