700770

(R)-SIPHOS-PE

97%

• Sinónimos: (11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1′, 7′-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine, N-Di[(R)-1-phenylethyl]-[(R)-1,1′-spirobiindane-7,7′-diyl]-phosphoramidite
• Fórmula empírica (notación de Hill): C₃₃H₃₂NO₂P
• Número de CAS: 500997-69-3
• Peso molecular: 505.59
• MDL number: MFCD08459342
• UNSPSC Code: 12352005
• PubChem Substance ID: 329762230

Propiedades

• assay: 97%
• form: powder
• optical activity: [α]22/D +337°, c = 1 in chloroform
• mp: 90-96 °C
• storage temp.: −20°C
• InChI: 1S/C33H32NO2P/c1-23(25-11-5-3-6-12-25)34(24(2)26-13-7-4-8-14-26)37-35-29-17-9-15-27-19-21-33(31(27)29)22-20-28-16-10-18-30(36-37)32(28)33/h3-18,23-24H,19-22H2,1-2H3/t23-,24-,33?/m1/s1
• InChI key: ZXLQLIDJAURBDD-HRPAVAKOSA-N

Descripción

Application

(R)-SIPHOS-PE can be used as:

• A catalyst in the preparation of tricyclic alkaloid (+)-aphanorphine via asymmetric carboamination and Friedel−Crafts reaction.
• A ligand in the synthesis of chiral ketones via hydroacylation of olefins using salicylaldehyde derivatives.
• A ligand in the enantioselective synthesis of substituted pyrrolidine derivatives via Pd-catalyzed alkene aminoarylation reactions.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves