415480
Chloroquine diphosphate salt
97%
Sinónimos:
N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt
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About This Item
Fórmula empírica (notación de Hill):
C18H26ClN3 · 2H3PO4
Número de CAS:
Peso molecular:
515.86
Beilstein:
4223142
Número CE:
Número MDL:
Código UNSPSC:
12352100
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Ensayo
97%
cadena SMILES
OP(O)(O)=O.OP(O)(O)=O.CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12
InChI
1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4)
Clave InChI
QKICWELGRMTQCR-UHFFFAOYSA-N
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Margaret A L Blackie et al.
Bioorganic & medicinal chemistry letters, 20(3), 1078-1080 (2009-12-26)
Synthesis of the potent antiplasmodial 4-aminoquinoline, phenylequine (PQ), is reported for the first time. PQ and the two analogues show increased efficacy in moving from the chloroquine sensitive D10 to the chloroquine resistant K1 strain in vitro. The in vivo
Clive L Yeates et al.
Journal of medicinal chemistry, 51(9), 2845-2852 (2008-04-10)
A series of diaryl ether substituted 4-pyridones have been identified as having potent antimalarial activity superior to that of chloroquine against Plasmodium falciparum in vitro and murine Plasmodium yoelii in vivo. These were derived from the anticoccidial drug clopidol through
David J Bacon et al.
Antimicrobial agents and chemotherapy, 51(4), 1172-1178 (2007-01-16)
In vitro drug susceptibility testing with the malaria parasite has been used to assess the antimalarial activities of new compounds and to monitor drug resistance in field isolates. We investigated the validity of a SYBR green I fluorescent-based assay under
Onyeka Onyeibor et al.
Journal of medicinal chemistry, 48(7), 2701-2709 (2005-04-02)
A series of analogues of cryptolepine (1) have been synthesized and evaluated for their in vitro antiplasmodial and cytotoxic properties. The IC(50) values of several compounds (11a, 11k-m, 11o, 13) against Plasmodium falciparum (strain K1) were <0.1 muM, 5-10-fold lower
Gajanan Wanare et al.
Bioorganic & medicinal chemistry letters, 20(15), 4675-4678 (2010-06-26)
Both the lack of a credible malaria vaccine and the emergence and spread of parasites resistant to most of the clinically used antimalarial drugs and drug combination have aroused an imperative need to develop new drugs against malaria. In present
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