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Merck

GRIN2C

glutamate receptor, ionotropic, N-methyl D-aspartate 2C

Sinónimos:
GluN2C, NMDAR2C, NR2C
Especie:
Human GRIN2C (2905), Mouse Grin2c (14813), Rat Grin2c (24411), domestic guinea pig Grin2c (100721967), naked mole-rat Grin2c (101698922), sheep GRIN2C (101102915), domestic cat GRIN2C (101091740), cow GRIN2C (535158), chicken GRIN2C (431090), dog GRIN2C (483302)
ID UniProtKB:
Q14957, B2RTT1
ID del gen:
  • Human(2905) Summary: This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
  • Mouse(14813) glutamate receptor, ionotropic, NMDA2C (epsilon 3)
  • Rat(24411) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • domestic guinea pig(100721967) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • naked mole-rat(101698922) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • sheep(101102915) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • domestic cat(101091740) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • cow(535158) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • chicken(431090) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • dog(483302) glutamate receptor, ionotropic, N-methyl D-aspartate 2C

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Small Molecule - Agonist

Referencia del producto
Descripción
Especie
T2006
L-Tyrosine hydrochloride, ≥98% (TLC),
Especie
mouse, rat, human
C3909
D-Cycloserine, synthetic,
Especie
human
M3262
N-Methyl-D-aspartic acid, ≥98% (TLC), solid,
Especie
human, rat
C6880
D-Cycloserine, ,
Especie
human, mouse, rat
A5930
N-Acetyl-Asp-Glu, ≥97% (TLC),
Especie
mouse, human, rat

Small Molecule - Allosteric Modulator

Referencia del producto
Descripción
Especie
A6981
Acamprosate calcium, ≥98% (HPLC), powder,
Especie
human
1000554
Acamprosate calcium, United States Pharmacopeia (USP) Reference Standard, monograph mol wt. 400.48 (C10H20CaN2O8S2),
Especie
human
BP1172
Acamprosate calcium, British Pharmacopoeia (BP) Reference Standard,
Especie
human

Small Molecule - Antagonist

Referencia del producto
Descripción
Especie
A8054
D(−)-2-Amino-5-phosphonopentanoic acid, NMDA receptor antagonist,
Especie
mouse, rat
I2892
Ifenprodil (+)-tartrate salt, ,
Especie
human
A0384
Arcaine sulfate salt, ,
Especie
human
A1910
(±)-2-Amino-4-phosphonobutyric acid, solid,
Especie
rat, human
F0778
Felbamate, ,
Especie
human

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
AB1592P
Anticuerpo anti-NMDAR2C, también reconoce las NMDAR2A y 2B, Chemicon®, from rabbit,
Reactividad de especies
rat
Aplicación
immunoprecipitation (IP)
western blot

Small Molecule - Blocker

Referencia del producto
Descripción
Especie
D8816
N-(3,3-Diphenylpropyl)glycinamide, >98% (HPLC), solid,
Especie
human
A7127
Agmatine sulfate salt, ≥97%, powder,
Especie
human
75517
Orphenadrine hydrochloride, ≥98.0% (AT),
Especie
human
Y0000100
Orphenadrine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Especie
human
Y0001181
Orphenadrine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Especie
human

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
P0547
Pentamidine isethionate salt, powder,
Especie
human
75517
Orphenadrine hydrochloride, ≥98.0% (AT),
Especie
human
Y0000100
Orphenadrine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Especie
human
Y0001181
Orphenadrine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
EHU075851
MISSION® esiRNA, targeting human GRIN2C,
Especie
human