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Merck

CDK1

cyclin-dependent kinase 1

Sinónimos:
CDC2, CDC28A, P34CDC2
Especie:
ID UniProtKB:
ID del gen:
  • Human(983) Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
  • Mouse(12534) cyclin-dependent kinase 1
  • Rat(54237) cyclin-dependent kinase 1
  • dog(488997) cyclin-dependent kinase 1
  • Zebrafish(80973) cyclin-dependent kinase 1
  • chicken(396252) cyclin-dependent kinase 1
  • naked mole-rat(101717463) cyclin-dependent kinase 1
  • domestic guinea pig(100735946) cyclin-dependent kinase 1
  • Goat(100861361) cyclin-dependent kinase 1
  • cow(281061) cyclin-dependent kinase 1
  • sheep(100216432) cyclin-dependent kinase 1

Custom & Knockdown Gene Products

Antibodies

Número de producto
Descripción
Reactividad de especies
Aplicación
Anti-phospho-CDK1/2/3(Thr14) Antibody, clone 23GB1430, Rabbit Monoclonal, clone 23GB1430, recombinant rabbit monoclonal, expressed in HEK293 cells,
Reactividad de especies
human, rat
Aplicación
flow cytometry
immunofluorescence

western blot
Anti-phospho-Cdk1 (Thr14, Tyr15)Antibody, clone CP3.2, clone CP3.2, from mouse,
Reactividad de especies
human
Aplicación
immunocytochemistry
western blot
Anti-Cdc2 Antibody, phospho-specific (Tyr15), Chemicon®, from rabbit,
Reactividad de especies
rat
Aplicación
western blot
Anticuerpo anti-Cdk1, clon A17.1.1, clone A17.1.1, Chemicon®, from mouse,
Reactividad de especies
xenopus, chicken, human, mouse, rat
Aplicación
activity assay
immunofluorescence

immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-Phospho-CDK1-Y15 antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot

Small Molecule - Inhibitor

Número de producto
Descripción
Especie
R547, ≥98% (HPLC),
Especie
human
Flavopiridol hydrochloride, ≥98% (HPLC), powder,
Especie
human
Roscovitine, ≥98% (TLC),
Especie
human, mouse, rat

esiRNA

Número de producto
Descripción
Especie
MISSION® esiRNA, targeting human CDK1,
Especie
human