M6625
6-Mercaptoguanosine
≥98%
Synonym(s):
2-Amino-6-mercaptopurine riboside, 6-Mercapto-2-aminopurine riboside, 6-Thioguanosine
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About This Item
Empirical Formula (Hill Notation):
C10H13N5O4S
CAS Number:
Molecular Weight:
299.31
EC Number:
MDL number:
UNSPSC Code:
12352204
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Assay
≥98%
SMILES string
Nc1nc(S)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
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Christian Reichardt et al.
The journal of physical chemistry. B, 115(12), 3263-3270 (2011-03-10)
Patients treated with the immunosuppressant and anticancer drugs 6-thioguanine, azathioprine, or mercaptopurine can metabolize and incorporate them in DNA as 6-thioguanosine. The skin of these patients is sensitive to UVA radiation, and long-term treatment can result in extremely high incidence
Monique Akoachere et al.
The Journal of biological chemistry, 282(16), 12112-12118 (2007-02-14)
Germination of Bacillus anthracis spores into the vegetative form is an essential step in anthrax pathogenicity. This process can be triggered in vitro by the common germinants inosine and alanine. Kinetic analysis of B. anthracis spore germination revealed synergy and
Qinguo Zheng et al.
Bioorganic & medicinal chemistry letters, 13(19), 3141-3144 (2003-09-03)
The preparation of N(2)-phenoxylacetyl-S(6)-(2,4-dinitrophenyl)-6-thioguanosine phosphoramidite and its subsequent incorporation into oligoribonucleotides is described. The identity of the oligonucleotides was confirmed by UV spectrophotometry and nucleoside composition analysis.
N T Vethe et al.
Scandinavian journal of clinical and laboratory investigation, 68(4), 277-285 (2008-07-09)
Depletion of guanine and deoxyguanine nucleotides by inhibition of inosine 5'-monophosphate dehydrogenase (IMPDH, EC 1.1.1.205) or introduction of 6-thioguanine nucleotide antimetabolites are two principles of retarding cell proliferation by interference with the cellular purine nucleotide pool. IMPDH activity may be
E L Christian et al.
Biochemistry, 37(50), 17618-17628 (1998-12-23)
The bacterial RNase P ribozyme is a site-specific endonuclease that catalyzes the removal of pre-tRNA leader sequences to form the 5' end of mature tRNA. While several specific interactions between enzyme and substrate that direct this process have been determined
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