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CGS-21680 hydrochloride hydrate

Name: CGS-21680 hydrochloride hydrate
Brand: SIGMA

≥98% (HPLC), Adenosine A2A receptor agonist, solid

Synonym(s):

2-p-(2-Carboxyethyl)phenethylamino-5′-N-ethylcarboxamidoadenosine hydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₂₉N₇O₆ · HCl · xH₂O

CAS Number:

124182-57-6

Molecular Weight:

535.98 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

24277698

NACRES:

NA.77

MDL number:

MFCD11045878

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

desiccated

Pricing and availability is not currently available.

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Product Name

CGS-21680 hydrochloride hydrate, solid

assay

≥98% (HPLC)

Quality Level

100

form

solid

storage condition

desiccated

color

white

solubility

DMSO: >10 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 20 mg/mL

storage temp.

−20°C

SMILES string

O.Cl.CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)nc(NCCc4ccc(CCC(O)=O)cc4)nc23

InChI

1S/C23H29N7O6.ClH.H2O/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32;;/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29);1H;1H2/t16-,17+,18-,22+;;/m0../s1

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1 of 1

This Item	PZ0136	B2417	E8284
Sigma-Aldrich C141 CGS-21680 hydrochloride hydrate	Sigma-Aldrich PZ0136 CP-100263 dihydrochloride hydrate	Sigma-Aldrich B2417 Benzamil hydrochloride hydrate	Sigma-Aldrich E8284 (E/Z)-Endoxifen Hydrochloride Hydrate
form solid	form solid	form solid	form solid
assay ≥98% (HPLC)	assay ≥97% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage condition desiccated	storage condition -	storage condition desiccated	storage condition desiccated
storage temp. −20°C	storage temp. room temp	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: >10 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 20 mg/mL	solubility H₂O: ≥5 mg/mL	solubility methanol: 10 mg/mL, DMSO: >20 mg/mL	solubility DMSO: >10 mg/mL

Biochem/physiol Actions

Adenosine receptor agonist, which possesses selectivity for A₂ verses A₁ receptors.

Disclaimer

Hygroscopic

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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4-Pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR)-A Novel Oncometabolite Modulating Cancer-Endothelial Interactions in Breast Cancer Metastasis.

Patrycja Koszalka et al.

International journal of molecular sciences, 23(10) (2022-05-29)

The accumulation of specific metabolic intermediates is known to promote cancer progression. We analyzed the role of 4-pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR), a nucleotide metabolite that accumulates in the blood of cancer patients, using the 4T1 murine in vivo breast cancer model, and

Diminished iron concentrations increase adenosine A(2A) receptor levels in mouse striatum and cultured human neuroblastoma cells.

Seema Gulyani et al.

Experimental neurology, 215(2), 236-242 (2008-11-18)

Brain iron insufficiency has been implicated in several neurological disorders. The dopamine system is consistently altered in studies of iron deficiency in rodent models. Changes in striatal dopamine D(2) receptors are directly proportional to the degree of iron deficiency. In

Caffeine treatment started before injury reduces hypoxic-ischemic white-matter damage in neonatal rats by regulating phenotypic microglia polarization.

Liu Yang et al.

Pediatric research (2022-02-28)

Reducing neuroinflammatory damage is an effective strategy for treating white-matter damage (WMD) in premature infants. Caffeine can ameliorate hypoxia-ischemia-induced brain WMD; however, its neuroprotective effect and mechanism against hypoxic-ischemic WMD remain unclear. We used 3-day-old Sprague-Dawley rats to establish a

Renal actions of a new adenosine agonist, CGS 21680A selective for the A2 receptor.

N Levens et al.

The Journal of pharmacology and experimental therapeutics, 257(3), 1005-1012 (1991-06-01)

This study compares the renal actions of the A2 selective adenosine agonist, CGS 21680A, with the A1 selective adenosine agonist, N6-cyclopentyladenosine (CPA), and the nonselective agonist, 5'-N-ethylcarboxamide adenosine (NECA), in the anesthetized dog. Initial receptor binding studies in dog brain

[3H]CGS 21680, a selective A2 adenosine receptor agonist directly labels A2 receptors in rat brain.

M F Jarvis et al.

The Journal of pharmacology and experimental therapeutics, 251(3), 888-893 (1989-12-01)

Characterization of the adenosine A2 receptor has been limited due to the lack of available ligands which have high affinity and selectivity for this adenosine receptor subtype. In the present study, the binding of a highly A2-selective agonist radioligand, [3H]CGS

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Global Trade Item Number

SKU	GTIN
C141-10MG	04061832081403
C141-25MG	04061832081410
C141-100MG	04061832089638
C141-5MG	04061833467510

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