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Sigma-Aldrich

L-Methionine-13C5,15N

98 atom % 13C, 98 atom % 15N, 95% (CP)

Synonym(s):

SILAC Amino Acid, L-Methionine-ul-13C,15N

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100 MG
$3,650.00
250 MG
$6,420.00

$3,650.00

Estimated to ship onApril 11, 2025

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100 MG
$3,650.00
250 MG
$6,420.00

About This Item

Linear Formula:
13CH3S13CH213CH213CH(15NH2)13CO2H
CAS Number:
202468-47-1
Molecular Weight:
155.17
MDL number:
MFCD00209757
UNSPSC Code:
12352209
PubChem Substance ID:
329759230
NACRES:
NA.12

$3,650.00

Estimated to ship onApril 11, 2025

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isotopic purity

98 atom % 13C
98 atom % 15N

Quality Level

200

Assay

95% (CP)

form

solid

optical activity

[α]25/D +23.1°, c = 1 in 1 M HCl

technique(s)

bio NMR: suitable
protein expression: suitable

mp

284 °C (dec.) (lit.)

mass shift

M+6

SMILES string

[13CH3]S[13CH2][13CH2][13C@H]([15NH2])[13C](O)=O

InChI

1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1/i1+1,2+1,3+1,4+1,5+1,6+1

InChI key

FFEARJCKVFRZRR-XAFSXMPTSA-N

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Application

L-Methionine-13C5,15N can be used as an internal standard in the analysis of amino acids in human plasma and serum using various analytical techniques.[1][2]

Packaging

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

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Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MBBD4758
MBBD4163
MBBC8569
MBBC5874
MBBC5670

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Aaron Issaian et al.
Haematologica (2021-05-14)
Band 3 (anion exchanger 1 - AE1) is the most abundant membrane protein in red blood cells (RBCs), the most abundant cell in the human body. A compelling model posits that - at high oxygen saturation - the N-term cytosolic
Comparison of orthogonal liquid and gas chromatography--mass spectrometry platforms for the determination of amino acid concentrations in human plasma
McGaw EA, et al.
Journal of Chromatography A, 1217(37), 5822-5831 (2010)
High-speed quantitative UPLC-MS analysis of multiple amines in human plasma and serum via precolumn derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate: application to acetaminophen-induced liver failure
Gray N, et al.
Analytical Chemistry, 89(4), 2478-2487 (2017)
Dominic G Roy et al.
Cell metabolism, 31(2), 250-266 (2020-02-06)
Epigenetic modifications on DNA and histones regulate gene expression by modulating chromatin accessibility to transcription machinery. Here we identify methionine as a key nutrient affecting epigenetic reprogramming in CD4+ T helper (Th) cells. Using metabolomics, we showed that methionine is

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