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225517

Sigma-Aldrich

Methoxylamine hydrochloride solution

25-30 wt. % in H2O

Synonym(s):

O-Methylhydroxylamine hydrochloride

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About This Item

Linear Formula:
CH3ONH2 · HCl
CAS Number:
Molecular Weight:
83.52
Beilstein:
3589723
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.

form

liquid

Quality Level

concentration

25-30 wt. % in H2O

refractive index

n20/D 1.4021

solubility

alcohol: soluble(lit.)
water: soluble(lit.)

density

1.1 g/mL at 25 °C

SMILES string

Cl[H].CON

InChI

1S/CH5NO.ClH/c1-3-2;/h2H2,1H3;1H

InChI key

XNXVOSBNFZWHBV-UHFFFAOYSA-N

Application

Methoxylamine hydrochloride was used as an derivatization agent during the structural investigation of novel epoxyisoprostane phospholipid in mildly oxidized low density lipoprotien[1].

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Dam. 1 - Skin Corr. 1 - Skin Sens. 1 - STOT RE 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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A D Watson et al.
The Journal of biological chemistry, 274(35), 24787-24798 (1999-08-24)
One of the earliest steps in the development of the atherosclerotic lesion is the accumulation of monocyte/macrophages within the vessel wall. Oxidized lipids present in minimally modified-low density lipoproteins (MM-LDL) contribute to this process by activating endothelial cells to express
Eva M Goellner et al.
Cancer research, 71(6), 2308-2317 (2011-03-17)
Glioblastoma multiforme (GBM) is a devastating brain tumor with poor prognosis and low median survival time. Standard treatment includes radiation and chemotherapy with the DNA alkylating agent temozolomide (TMZ). However, a large percentage of tumors are resistant to the cytotoxic
Jiang-bo Tang et al.
Neuro-oncology, 13(5), 471-486 (2011-03-08)
Temozolomide (TMZ) is the preferred chemotherapeutic agent in the treatment of glioma following surgical resection and/or radiation. Resistance to TMZ is attributed to efficient repair and/or tolerance of TMZ-induced DNA lesions. The majority of the TMZ-induced DNA base adducts are
April M Luke et al.
Mutation research, 694(1-2), 65-71 (2010-09-21)
Single strand breaks (SSBs) are one of the most frequent DNA lesions caused by endogenous and exogenous agents. The most utilized alkaline-based assays for SSB detection frequently give false positive results due to the presence of alkali-labile sites that are
Melissa L Fishel et al.
Molecular aspects of medicine, 28(3-4), 375-395 (2007-06-15)
With our growing understanding of the pathways involved in cell proliferation and signaling, targeted therapies, in the treatment of cancer are entering the clinical arena. New and emerging targets are proteins involved in DNA repair pathways. Inhibition of various proteins

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