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1337809

USP

Imipenem monohydrate

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

(5R,6S)-6-[(1R)-1-Hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate, Primaxin monohydrate, Tienam monohydrate

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About This Item

Empirical Formula (Hill Notation):
C12H17N3O4S · H2O
CAS Number:
74431-23-5
Molecular Weight:
317.36
MDL number:
MFCD09753321
UNSPSC Code:
41116107
PubChem Substance ID:
329750155
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

imipenem

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

O.C[C@@H](O)[C@@H]1[C@H]2CC(SCCNC=N)=C(N2C1=O)C(O)=O

InChI

1S/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/m1./s1

InChI key

GSOSVVULSKVSLQ-JJVRHELESA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Imipenem monohydrate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Imipenem
  • Imipenem and Cilastatin for Injectable Suspension
  • Imipenem and Cilastatin for Injection

Biochem/physiol Actions

Imipenem monohydrate is a broad spectrum B-lactam antibiotic. It is a member of the carbapenem class of "magic bullet" antibiotics for severe infections.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Imipenem heteroresistance: high prevalence among Enterobacteriaceae Klebsiella pneumoniae carbapenemase producers.
Carolina Silva Nodari et al.
Journal of medical microbiology, 64(Pt 1), 124-126 (2014-10-30)
Hao-Yuan Lee et al.
Critical care medicine, 42(5), 1081-1088 (2014-01-08)
Acinetobacter baumannii complex bacteremia has been identified increasingly in critical patients admitted in ICUs. Notably, A. baumannii complex bacteremia has a high mortality rate, yet the risk factors associated with mortality remain unclear and controversial. Retrospective study. All adult ICUs
Anne-Laure Michon et al.
Journal of pediatric hematology/oncology, 36(3), e165-e168 (2013-05-15)
Roseomonas are described as opportunistic pathogens rarely involved in human infections. Their identification requires molecular methods and their antimicrobial susceptibility pattern varies according to the species. We report the first case of bacteremia due to Roseomonas mucosa in a child
The deadly impact of extreme drug resistance in Acinetobacter baumannii.
Brad Spellberg et al.
Critical care medicine, 42(5), 1289-1291 (2014-04-17)
Yi-Jiun Pan et al.
Antimicrobial agents and chemotherapy, 59(2), 1038-1047 (2014-12-03)
Klebsiella pneumoniae is an important human pathogen associated with a variety of diseases, and the prevalence of multidrug-resistant K. pneumoniae (MDRKP) is rapidly increasing. Here we determined the capsular types of 85 carbapenem-resistant K. pneumoniae (CRKP) strains by wzc sequencing

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