Skip to Content
Merck
All Photos(2)

Key Documents

E0656

Sigma-Aldrich

ER-27319

≥98% (HPLC), solid

Synonym(s):

10-(3-Aminopropyl)-3,4-dimethyl-9-acridone oxalate

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C20H22N2O5
CAS Number:
Molecular Weight:
370.40
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Pricing and availability is not currently available.

Quality Level

Assay

≥98% (HPLC)

form

solid

solubility

DMSO: 28 mg/mL

storage temp.

2-8°C

SMILES string

OC(=O)C(O)=O.Cc1ccc2C(=O)c3ccccc3N(CCCN)c2c1C

InChI

1S/C18H20N2O.C2H2O4/c1-12-8-9-15-17(13(12)2)20(11-5-10-19)16-7-4-3-6-14(16)18(15)21;3-1(4)2(5)6/h3-4,6-9H,5,10-11,19H2,1-2H3;(H,3,4)(H,5,6)

InChI key

IIELZHYJYZBSGG-UHFFFAOYSA-N

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
A9789S5192D6317
ER-27319 ≥98% (HPLC), solid

E0656

ER-27319

SB 222200 ≥98% (HPLC), solid

S5192

SB 222200

DMeOB ≥98% (HPLC), solid

D6317

DMeOB

form

solid

form

solid

form

solid

form

solid

solubility

DMSO: 28 mg/mL

solubility

H2O: 2 mg/mL (Aqueous solutions are stable over a wide range of pH at room temperature.), DMSO: 20 mg/mL, methanol: 20 mg/mL

solubility

DMSO: soluble ~28 mg/mL, H2O: insoluble

solubility

DMSO: ~28 mg/mL, H2O: insoluble

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Biochem/physiol Actions

ER-27319 inhibits Syk activation with an IC50 = 10 μM. ER-27319 inhibits Syk by preventing the phosphorylated ITAM domain of FcεRI γ from activating Syk. ER-27319 does NOT inhibit previously activated Syk.[1]
Selective Syk inhibitor. Induces tyrosine phosphorylation of Syk that has been demonstrated as critical for degranulation.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


  • Certificates of Analysis (COA)

    Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

    Need A Sample COA?

    This is a sample Certificate of Analysis (COA) and may not represent a recently manufactured lot of this specific product.

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    K Moriya et al.
    Proceedings of the National Academy of Sciences of the United States of America, 94(23), 12539-12544 (1997-11-14)
    Engagement of the mast cell high-affinity receptor for immunoglobulin E (IgE), FcepsilonRI, induces tyrosine phosphorylation of Syk, a non-receptor tyrosine kinase, that has been demonstrated as critical for degranulation. Herein we describe a synthetic compound, ER-27319, as a potent and

    Articles

    Discover Bioactive Small Molecules for Kinase Phosphatase Biology

    Discover Bioactive Small Molecules for Kinase Phosphatase Biology

    Discover Bioactive Small Molecules for Kinase Phosphatase Biology

    Discover Bioactive Small Molecules for Kinase Phosphatase Biology

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service