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C0330

Sigma-Aldrich

Ciprofibrate

Synonym(s):

2-[p-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid

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About This Item

Empirical Formula (Hill Notation):
C13H14Cl2O3
CAS Number:
52214-84-3
Molecular Weight:
289.15
EC Number:
257-744-6
MDL number:
MFCD00467135
UNSPSC Code:
41116107
PubChem Substance ID:
24278288
NACRES:
NA.77

form

powder

Quality Level

200

storage temp.

2-8°C

SMILES string

CC(C)(Oc1ccc(cc1)C2CC2(Cl)Cl)C(O)=O

InChI

1S/C13H14Cl2O3/c1-12(2,11(16)17)18-9-5-3-8(4-6-9)10-7-13(10,14)15/h3-6,10H,7H2,1-2H3,(H,16,17)

InChI key

KPSRODZRAIWAKH-UHFFFAOYSA-N

Gene Information

human ... PPARA(5465)

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Biochem/physiol Actions

Peroxisome proliferator-activated receptor α (PPARα) agonist

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H350

Precautionary Statements

P201 - P308 + P313

Hazard Classifications

Carc. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chuhan Chung et al.
Advances in experimental medicine and biology, 617, 591-597 (2008-05-24)
Pigment epithelium-derived factor (PEDF) is an endogenous antiangiogenic protein that also possesses antitumor activity. The mechanisms by which PEDF exerts its actions remains poorly understood. We sought to understand the role of PEDF in hepatocellular carcinoma (HCC), a hypervascular malignancy
Chae Hwa Kwon et al.
Toxicology, 244(1), 13-24 (2007-12-18)
Peroxisome proliferator-activated receptor gamma (PPARgamma) agonists have been reported to induce apoptosis in a variety of cell types including renal proximal epithelial cells. However, the underlying mechanism of cell death induced by PPARgamma agonists has not been clearly defined in
Wei Xie et al.
Archives of toxicology, 83(10), 909-924 (2009-06-23)
Perfluorooctanesulfonamides, such as N-ethyl perfluorooctanesulfonamidoethanol (N-EtFOSE), are large scale industrial chemicals but their disposition and toxicity are poorly understood despite significant human exposure. The hypothesis that subacute exposure to N-EtFOSE, a weak peroxisome proliferator, causes a redox imbalance in vivo
Fabiana D Mendes et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(24), 2361-2368 (2011-07-19)
A rapid, sensitive and specific method for quantifying ciprofibrate in human plasma using bezafibrate as the internal standard (IS) is described. The sample was acidified prior extraction with formic acid (88%). The analyte and the IS were extracted from plasma
P Passilly et al.
Biochemical pharmacology, 58(6), 1001-1008 (1999-10-06)
The basic mechanism(s) by which peroxisome proliferators activate peroxisome proliferator-activated receptors (PPARs) is (are) not yet fully understood. Given the diversity of peroxisome proliferators, several hypotheses of activation have been proposed. Among them is the notion that peroxisome proliferators could
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Chromatograms

application for HPLC

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