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Key Documents

88315

Sigma-Aldrich

Thesit®

for membrane research

Synonym(s):

Polyethylene glycol dodecyl ether, Polyethylene glycol 400 dodecyl ether, Hydroxypolyethoxydodecane, Lauromacrogol, Macrogol lauryl ether, Polidocanol

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About This Item

Linear Formula:
HO(CH2CH2O)n(CH2)11CH3
CAS Number:
MDL number:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.21

grade

for membrane research

Quality Level

description

non-ionic

form

solid

mol wt

average mol wt 583

impurities

≤1 ppm peroxides (as H2O2)

CMC

0.1 mM (20-25°C)

SMILES string

CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO

InChI

1S/C58H118O24/c1-2-3-4-5-6-7-8-9-10-11-13-60-15-17-62-19-21-64-23-25-66-27-29-68-31-33-70-35-37-72-39-41-74-43-45-76-47-49-78-51-53-80-55-57-82-58-56-81-54-52-79-50-48-77-46-44-75-42-40-73-38-36-71-34-32-69-30-28-67-26-24-65-22-20-63-18-16-61-14-12-59/h59H,2-58H2,1H3

InChI key

IEQAICDLOKRSRL-UHFFFAOYSA-N

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Application

Suggested substitute for Lubrol in the preparation of G protein from bovine brain.
Thesit has been used in the reaction buffer to reduce the background sedimentation.

Biochem/physiol Actions

Thesit/Polidocanol possesses in vitro and in vivo anti-angiogenic effects. This sclerosant is mainly used for sclerotherapy.

Legal Information

Thesit is a registered trademark of Desitin Arzneimittel GmbH

Pictograms

Exclamation markEnvironment

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Synthesis and use of biotinylated beta gamma complexes prepared from bovine brain G proteins.
J Dingus et al.
Methods in enzymology, 237, 457-471 (1994-01-01)
Measuring protein binding to F-actin by co-sedimentation
Heier JA, et al.
Journal of Visualized Experiments, e55613-e55613 (2017)
K Parsi et al.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 41(2), 267-277 (2010-12-25)
To investigate the in vitro effects of detergent sclerosants sodium tetradecyl sulphate (STS) and polidocanol (POL) on clot formation and lysis. clot kinetics were assessed in whole blood by thromboelastography (TEG®) and rotational thromboelastometry (ROTEM®). Fibrinogen was measured by the
Polidocanol (Lauromacrogol 400) has anti-angiogenic effects in vitro and in vivo
Doganci S, et al.
European Review for Medical and Pharmacological Sciences, 20(7), 1384-1389 (2016)
Sabrina G Fabi et al.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 38(7 Pt 2), 1112-1127 (2012-01-25)
The aged hand is characterized by cutaneous and dermal atrophy, with deep intermetacarpal spaces, prominent bones and tendons, and bulging reticular veins. Epidermal changes include solar lentigines, seborrheic keratoses, actinic keratoses, skin laxity, rhytides, tactile roughness, and telangiectasia. A Medline

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