Skip to Content
Merck
All Photos(1)

Key Documents

55460

Sigma-Aldrich

Hydroxylamine hydrochloride

puriss. p.a., ACS reagent, ≥99.0% (RT)

Synonym(s):

Hydroxylammonium chloride

Sign Into View Organizational & Contract Pricing


About This Item

Linear Formula:
NH2OH · HCl
CAS Number:
Molecular Weight:
69.49
Beilstein:
3539763
EC Number:
MDL number:
UNSPSC Code:
12352300
PubChem Substance ID:
NACRES:
NB.24
form:
powder or crystals
Pricing and availability is not currently available.

grade

ACS reagent
puriss. p.a.

Quality Level

vapor pressure

0.001 hPa ( 50 °C)

Assay

≥99.0% (RT)

form

powder or crystals

technique(s)

inhibition assay: suitable

ign. residue

≤0.05% (as SO4)

pH

2.5-3.5 (25 °C, 50 mg/mL in H2O)

mp

155-157 °C (dec.) (lit.)

density

1.67 g/mL at 25 °C (lit.)

anion traces

sulfate (SO42-): ≤50 mg/kg

cation traces

Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg
heavy metals: ≤5 ppm (by ICP)

SMILES string

Cl.NO

InChI

1S/ClH.H3NO/c;1-2/h1H;2H,1H2

InChI key

WTDHULULXKLSOZ-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Hydroxylamine hydrochloride (Hydroxylammonium chloride) is the hydrochloride salt of hydroxylamine. It participates in the synthesis of 1,2,4-oxadiazoles.[1]

Application



  • Mass Spectrometry-Based Atlas of Extracellular Matrix Proteins across 25 Mouse Organs.: This study utilized hydroxylamine hydrochloride in mass spectrometry to analyze the extracellular matrix proteins in various mouse organs, offering insights into tissue-specific protein compositions (McCabe et al., 2023).


  • Analysis of extracellular metabolome by HS-SPME/GC-MS: Optimization and application in a pilot study to evaluate galactosamine-induced hepatotoxicity.: Hydroxylamine hydrochloride was employed in HS-SPME/GC-MS to optimize the analysis of extracellular metabolites, crucial for assessing hepatotoxic effects (Araújo et al., 2018).


  • Improved production and processing of ⁸⁹Zr using a solution target.: This research enhanced the production process of zirconium-89 with hydroxylamine hydrochloride, improving efficiency and yield for medical imaging applications (Pandey et al., 2016).


  • Evaluation of the physicochemical properties and the biocompatibility of polyethylene glycol-conjugated gold nanoparticles: A formulation strategy for siRNA delivery.: The study used hydroxylamine hydrochloride to modify gold nanoparticles, improving their biocompatibility and effectiveness in siRNA delivery systems (Rahme et al., 2015).


  • Preparation and photocatalytic performance of Fe (III)-amidoximated PAN fiber complex for oxidative degradation of azo dye under visible light irradiation.: Hydroxylamine hydrochloride was used in the synthesis of Fe(III)-amidoximated PAN fibers, enhancing their photocatalytic degradation properties for environmental applications (Dong et al., 2010).


Biochem/physiol Actions

MAO inhibitor; inhibits platelet aggregation.

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Carc. 2 - Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral

Target Organs

spleen

Storage Class Code

4.1A - Other explosive hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Selective dissolution of manganese oxides from soils and sediments with acidified hydroxylamine hydrochloride.
Chao TT.
Soil Science Society of America Journal. Soil Science Society of America, 36(5), 764-768 (1972)
One-step Beckmann rearrangement from carbonyl compounds and hydroxylamine hydrochloride in Al2O3/CH3SO3H (AMA) as a new reagent.
Sharghi H and Sarvari MH.
J. Chem. Res. (M), 2001(10), 446-449 (2001)
Transamidation of primary amides with amines using hydroxylamine hydrochloride as an inorganic catalyst.
C Liana Allen et al.
Angewandte Chemie (International ed. in English), 51(6), 1383-1386 (2012-01-04)
Satu Hänninen et al.
Bio-protocol, 7(9), e2268-e2268 (2017-05-05)
Glycerophospholipids consist of a glycerophosphate backbone to which are esterified two acyl chains and a polar head group. The head group (e.g., choline, ethanolamine, serine or inositol) defines the glycerophospholipid class, while the acyl chains together with the head group
Magnesia-supported hydroxylamine hydrochloride in the presence of sodium carbonate as an efficient reagent for the synthesis of 1, 2, 4-oxadiazoles from nitriles.
Kaboudin B and Saadati F.
Tetrahedron Letters, 48(16), 2829-2832 (2007)

Questions

1–2 of 2 Questions  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service