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Y0001025

Benazepril hydrochloride

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(3S)-3-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C24H28N2O5 · HCl
CAS Number:
Molecular Weight:
460.95
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

Pricing and availability is not currently available.

grade

pharmaceutical primary standard

API family

benazepril

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl[H].CCOC(=O)[C@H](CCc1ccccc1)N[C@H]2CCc3ccccc3N(CC(O)=O)C2=O

InChI

1S/C24H28N2O5.ClH/c1-2-31-24(30)20(14-12-17-8-4-3-5-9-17)25-19-15-13-18-10-6-7-11-21(18)26(23(19)29)16-22(27)28;/h3-11,19-20,25H,2,12-16H2,1H3,(H,27,28);1H/t19-,20-;/m0./s1

InChI key

VPSRQEHTHIMDQM-FKLPMGAJSA-N

Gene Information

human ... ACE(1636)

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Show Differences

1 of 4

This Item
RAB0528RAB1353RAB1438
Gene Information

human ... ADAM8(101)

Gene Information

human ... ADAM9(8754)

Gene Information

human ... CD84(8832)

Gene Information

human ... EPHA2(1969)

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 1.8 ng/mL
standard curve range: 1.563-100 ng/mL

assay range

inter-assay cv: <10%
intra-assay cv: <12%
sensitivity: 45 pg/mL

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 2 ng/mL
standard curve range: 0.819-200 ng/mL

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.08 ng/mL
standard curve range: 0.082-20 ng/mL

input

sample type serum
sample type cell culture supernatant(s)
sample type plasma

input

sample type urine
sample type plasma
sample type serum
sample type cell culture supernatant(s)

input

sample type plasma
sample type serum
sample type cell culture supernatant(s)

input

sample type serum
sample type plasma
sample type cell culture supernatant(s)

detection method

colorimetric

detection method

colorimetric

detection method

colorimetric

detection method

colorimetric

technique(s)

ELISA: suitable

technique(s)

ELISA: suitable

technique(s)

ELISA: suitable

technique(s)

ELISA: suitable

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Benazepril hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Benazepril is a long-acting angiotensin converting enzyme (ACE) inhibitor.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

Pictograms

Health hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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    Simultaneous determination of benazepril hydrochloride and hydrochlorothiazide in tablets by second-order derivative spectrophotometry.
    Panderi E I.
    Journal of Pharmaceutical and Biomedical Analysis, 21(2), 257-265 (1999)
    Application of LC and HPTLC-densitometry for the simultaneous determination of benazepril hydrochloride and hydrochlorothiazide.
    El-Gindy A, et al.
    Journal of Pharmaceutical and Biomedical Analysis, 25(2), 171-179 (2001)
    Bjoern B Burckhardt et al.
    Journal of pharmaceutical and biomedical analysis, 96, 118-126 (2014-04-18)
    Although serum and plasma are the biological fluids of choice for pharmacokinetic determination of drugs in adults, it is desirable to elucidate noninvasive methods which can be used for investigations in vulnerable groups such as children. If the drug properties
    Bjoern B Burckhardt et al.
    Biomedical chromatography : BMC, 28(12), 1679-1691 (2014-05-03)
    The benefit-risk ratio of combined blocking by the direct renin inhibitor aliskiren and an angiotensin-converting enzyme inhibitor (e.g. enalapril) on the renin-angiotensin-aldosterone system is discussed. No method was available for simultaneous determination of both drugs in urine. A novel sensitive
    Haruka Nishimuta et al.
    Drug metabolism and disposition: the biological fate of chemicals, 42(9), 1522-1531 (2014-07-06)
    Hydrolysis plays an important role in metabolic activation of prodrugs. In the current study, species and in vitro system differences in hepatic and extrahepatic hydrolysis were investigated for 11 prodrugs. Ten prodrugs in the data set are predominantly hydrolyzed by

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