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682160-M

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Xestospongin C, Xestospongia sp.

An oxaquinolizidine alkaloid isolated from a marine sponge.

Synonym(s):

Xestospongin C, Xestospongia sp., XeC

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About This Item

Empirical Formula (Hill Notation):
C28H50N2O2
Molecular Weight:
446.71
UNSPSC Code:
12352200

Pricing and availability is not currently available.

Quality Level

Assay

≥98% (HPLC)

form

film

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white to off-white

solubility

DMSO: 1 mg/mL
ethanol: 1 mg/mL
methanol: 1 mg/mL

storage temp.

−20°C

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This Item
X2628499610580555
assay

≥98% (HPLC)

assay

-

assay

≥97% (HPLC)

assay

≥95% (NMR)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 1 mg/mL, methanol: 1 mg/mL

solubility

DMSO: soluble

solubility

DMSO: 10 mg/mL, ethanol: 5 mg/mL

solubility

methanol: 1 mg/mL, DMSO: 10 mg/mL

General description

A macrocyclic bis-1-oxaquinolizidine natural product isolated from a marine sponge. A very potent, reversible and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 358 nM) that does not interact with the IP3-binding site. Displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (Ry1R). Also blocks bradykinin- and carbamylcholine-induced Ca2+ efflux from the ER stores in a reversible manner.
An oxaquinolizidine alkaloid isolated from a marine sponge. A very potent, reversible, and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 358 nM) that does not interact with the IP3-binding site. Displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (RyR-1). Also blocks bradykinin- and carbamylcholine-induced Ca2+ efflux from the endoplasmic reticulum stores in a reversible manner.

Biochem/physiol Actions

Primary Target
IP3-mediated Ca2+ release
Target IC50: 358 nM in blocking IP3-mediated Ca2+ release

Warning

Toxicity: Harmful (C)

Preparation Note

Sonication may be required to achieve complete solubilization.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Oka, T., et al. 2002. Br. J. Pharmacol.135, 1959.
Gafni, J., et al. 1997. Neuron 19, 723.
Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
Nakagawa, M., et al. 1984. Tetrahedron Lett.25, 3227.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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