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20-107

Sigma-Aldrich

Peroxynitrite

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20 MG
$1,250.00

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Estimated to ship onFebruary 22, 2025


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20 MG
$1,250.00

About This Item

UNSPSC Code:
41116012
eCl@ss:
32160405
NACRES:
NA.41

$1,250.00


Availability

Estimated to ship onFebruary 22, 2025


Request a Bulk Order

form

liquid

Quality Level

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

shipped in

dry ice

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516620SCT035N0409
form

liquid

form

liquid

form

-

form

buffered aqueous solution

manufacturer/tradename

Upstate®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

-

technique(s)

western blot: suitable

technique(s)

-

technique(s)

cell based assay: suitable

technique(s)

immunohistochemistry (frozen sections): 1:1000 using methacarn-fixed, frozen sections of human Alzheimer′s Disease brain, indirect ELISA: 1:1,000 using nitrated-BSA, indirect immunofluorescence: 1:1,000 using A549 cells metabolically labeled with 3-nitrotyrosine, microarray: suitable, western blot: 1:1,000 using nitrated-BSA

shipped in

dry ice

shipped in

wet ice

shipped in

ambient

shipped in

dry ice

General description

Peroxynitrite (ONOO−) is a powerful oxidant formed by the collision of nitric oxide and superoxide.[1]

Application

Peroxynitrite has been used to induce pericyte contraction in mouse brains.[1] It has also been used for the preparation of positive control nitrated protein standards in immunohistochemical studies.[2]

Biochem/physiol Actions

Peroxynitrite (ONOO−) exhibits bactericidal activity.[3] It promotes cell death and contributes to the signal-transduction process, mitochondrial function, and apoptotic pathway. The formation of peroxynitrite has been associated with the development of various diseases including vascular diseases, ischemia-reperfusion injury, circulatory shock, inflammation, pain, and neurodegeneration.[1]

Quality

Routinely evaluated by treating non-stimulated A431 cells.

Physical form

0.3M NaOH

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Corrosion

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2

Storage Class Code

8B - Non-combustible corrosive hazardous materials

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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A Patel et al.
Journal of endocrinological investigation, 25(8), 675-683 (2002-09-21)
Nitric oxide (NO) is a reactive cell signal that controls vascular tone and is generated by inducible (iNOS), endothelial (eNOS) and neuronal (nNOS) NO synthase (NOS). We hypothesized that NO could be important for growth of thyroid tumors and tested
Csaba Szabó et al.
Nature reviews. Drug discovery, 6(8), 662-680 (2007-08-02)
Peroxynitrite--the product of the diffusion-controlled reaction of nitric oxide with superoxide radical--is a short-lived oxidant species that is a potent inducer of cell death. Conditions in which the reaction products of peroxynitrite have been detected and in which pharmacological inhibition
L Zhu et al.
Archives of biochemistry and biophysics, 298(2), 452-457 (1992-11-01)
Peroxynitrite is a strong oxidant formed by macrophages and potentially by other cells that produce nitric oxide and superoxide. Peroxynitrite was highly bactericidal, killing Escherichia coli in direct proportion to its concentration with an LD50 of 250 microM at 37
Oxidative chemistry of peroxynitrite.
Beckman, J S, et al.
Test, 233, 229-240 (1994)
Hongjun Jin et al.
Current protocols in toxicology, Chapter 17, Unit 17-Unit 17 (2012-04-19)
Reactive nitrogen species (RNS) and reactive oxygen species (ROS) are derived as a result of inflammation and oxidative stress and can result in protein modifications. As such, these protein modifications are used as biomarkers for inflammation and oxidative stress. In

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