182517
Arp2/3 Complex Inhibitor I, Inactive Control, CK-689
The Arp2/3 Complex Inhibitor I, Inactive Control, CK-689, also referenced under CAS 170930-46-8, controls the biological activity of Arp2/3. This small molecule/inhibitor is primarily used for Cell Structure applications.
Synonym(s):
Arp2/3 Complex Inhibitor I, Inactive Control, CK-689, N-(2-(1H-Indol-3-yl)ethyl)-2-methoxy-acetamide, CK-1828689
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About This Item
Empirical Formula (Hill Notation):
C13H16N2O2
CAS Number:
Molecular Weight:
232.28
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable indolyl-methoxyacetamide that exhibits no Arp2/3 inhibitory activity and serves as an inactive control for CK-666 (Cat. No. 182515) in both cell-based and cell-free experiments.
A cell-permeable indolyl-methoxyacetamide that exhibits no Arp2/3 inhibitory activity and serves as an inactive control for CK-666 (Cat. No. 182515) in both cell-based and cell-free experiments.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Nolen, B.J., et al. 2009. Nature460, 1031.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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eLife, 12 (2023-12-12)
Antigen-induced B-cell receptor (BCR) signaling is critical for initiating and regulating B-cell activation. The actin cytoskeleton plays essential roles in BCR signaling. Upon encountering cell-surface antigens, actin-driven B-cell spreading amplifies signaling, while B-cell contraction following spreading leads to signal attenuation.
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The baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV), a pathogen of lepidopteran insects, has a striking dependence on the host cell actin cytoskeleton. During the delayed-early stage of infection, AcMNPV was shown to induce the accumulation of actin at the cortex of infected cells. However, the dynamics and
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When crawling through the body, leukocytes often traverse tissues that are densely packed with extracellular matrix and other cells, and this raises the question: How do leukocytes overcome compressive mechanical loads? Here, we show that the actin cortex of leukocytes
Giulia Cazzagon et al.
iScience, 26(7), 107129-107129 (2023-07-12)
Although the formin-nucleated actomyosin cortex has been shown to drive the changes in cell shape that accompany animal cell division in both symmetric and asymmetric cell divisions, the mitotic role of cortical Arp2/3-nucleated actin networks remain unclear. Here using asymmetrically
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