14-455
Rap1 Assay Reagent (Ral GDS-RBD, agarose), 650 µg
Reagent (Ral GDS-RBD, agarose). A GST-tagged fusion protein, corresponding to amino acids 788-884 of human Ral GDS-Rap binding domain (RBD), for use in Affinity Binding Assays.
Synonym(s):
Ral GDS-RBD Assay Reagent, Rap1 Detection Reagent
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About This Item
UNSPSC Code:
12352204
eCl@ss:
32160405
NACRES:
NA.41
Recommended Products
biological source
human
Quality Level
form
liquid
manufacturer/tradename
Upstate®
technique(s)
affinity binding assay: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
Gene Information
human ... TERF2IP(54386)
General description
A GST-tagged fusion protein, corresponding to amino acids 788-884 of human Ral GDS-Rap binding domain (RBD)
Product Source: expressed in E. coli
Quality
routinely evaluated by immunoblot analysis
Storage and Stability
6 months at -20C
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Measurement of GTP-bound Ras-like GTPases by activation-specific probes.
M van Triest et al.
Methods in enzymology, 333, 343-348 (2001-06-13)
Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor
Herrmann, C, et al
The Journal of Biological Chemistry, 271, 6794-6800 (1996)
J F Rebhun et al.
The Journal of biological chemistry, 275(45), 34901-34908 (2000-08-10)
Although the Ras subfamily of GTPases consists of approximately 20 members, only a limited number of guanine nucleotide exchange factors (GEFs) that couple extracellular stimuli to Ras protein activation have been identified. Furthermore, no novel downstream effectors have been identified
B Franke et al.
The EMBO journal, 16(2), 252-259 (1997-01-15)
Rap1 is a small, Ras-like GTPase whose function and regulation are still largely unknown. We have developed a novel assay to monitor the active, GTP-bound form of Rap1 based on the differential affinity of Rap1GTP and Rap1GDP for the Rap
Amlodipine potentiates metalloproteinase activity and accelerates elastin degradation in a model of aneurysmal disease.
J R Boyle,I M Loftus,S Goodall,M Crowther,P R Bell,M M Thompson
European Journal of Vascular and Endovascular Surgery null
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